TY - JOUR
T1 - Predicting Cardiovascular Risk in Type 2 Diabetes
T2 - the Heterogeneity Challenges
AU - Gore, M. Odette
AU - McGuire, Darren K
AU - Lingvay, Ildiko
AU - Rosenstock, Julio
N1 - Publisher Copyright:
© 2015, Springer Science+Business Media New York.
PY - 2015/7/4
Y1 - 2015/7/4
N2 - Type 2 diabetes mellitus has reached epidemic proportions around the world, and the increase in cardiovascular risk attributable to diabetes estimated to range from 2- to 4-fold poses grave public health concern. Though in some contexts type 2 diabetes has been equated with coronary heart disease equivalent risk, there is considerable evidence that incremental cardiovascular risk does not uniformly affect all people with type 2 diabetes. This heterogeneity in cardiovascular risk is multifactorial and only partially understood but is a key consideration for our understanding of the nexus of diabetes and cardiovascular disease and for the development of optimal and individualized cardiovascular risk reduction strategies. This review provides a brief synopsis of the concept of cardiovascular risk heterogeneity in diabetes, including epidemiologic evidence, discussion of established and potential determinants of heterogeneity, and clinical, research, and regulatory implications.
AB - Type 2 diabetes mellitus has reached epidemic proportions around the world, and the increase in cardiovascular risk attributable to diabetes estimated to range from 2- to 4-fold poses grave public health concern. Though in some contexts type 2 diabetes has been equated with coronary heart disease equivalent risk, there is considerable evidence that incremental cardiovascular risk does not uniformly affect all people with type 2 diabetes. This heterogeneity in cardiovascular risk is multifactorial and only partially understood but is a key consideration for our understanding of the nexus of diabetes and cardiovascular disease and for the development of optimal and individualized cardiovascular risk reduction strategies. This review provides a brief synopsis of the concept of cardiovascular risk heterogeneity in diabetes, including epidemiologic evidence, discussion of established and potential determinants of heterogeneity, and clinical, research, and regulatory implications.
KW - Cardiovascular disease
KW - Cardiovascular risk factors
KW - Diabetes mellitus
KW - Macrovascular complications
UR - http://www.scopus.com/inward/record.url?scp=84930621074&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84930621074&partnerID=8YFLogxK
U2 - 10.1007/s11886-015-0607-7
DO - 10.1007/s11886-015-0607-7
M3 - Review article
C2 - 26031671
AN - SCOPUS:84930621074
SN - 1523-3782
VL - 17
JO - Current Cardiology Reports
JF - Current Cardiology Reports
IS - 7
M1 - 54
ER -