TY - JOUR
T1 - Precursor cell division during the immune response in vitro
T2 - antigen‐induced and “spontaneous” antibody‐forming cells
AU - Kettman, J.
AU - Yin, E.
AU - Dutton, R. W.
PY - 1973/10
Y1 - 1973/10
N2 - “Background” or “spontaneous” plaque‐forming cells (PFC) which arise during in vitro culture of mouse spleen cells may be eliminated by a hot thymidine pulse. This does not prevent the subsequent addition of sheep red blood cells (SRBC) or trinitrophenylated (TNP) SRBC eliciting a primary immune response. Using mouse spleen cells, resently primed by carrier (SRBC), it was found that an early “hot pulse” (for the first 24 hours of culture) can eliminate the anti‐SRBC response, but not the primary anti‐TNP response which is dependent on carrier‐specific, θ‐bearing, radioresistant spleen cells.
AB - “Background” or “spontaneous” plaque‐forming cells (PFC) which arise during in vitro culture of mouse spleen cells may be eliminated by a hot thymidine pulse. This does not prevent the subsequent addition of sheep red blood cells (SRBC) or trinitrophenylated (TNP) SRBC eliciting a primary immune response. Using mouse spleen cells, resently primed by carrier (SRBC), it was found that an early “hot pulse” (for the first 24 hours of culture) can eliminate the anti‐SRBC response, but not the primary anti‐TNP response which is dependent on carrier‐specific, θ‐bearing, radioresistant spleen cells.
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U2 - 10.1002/eji.1830031014
DO - 10.1002/eji.1830031014
M3 - Article
C2 - 4797250
AN - SCOPUS:0015817838
SN - 0014-2980
VL - 3
SP - 655
EP - 656
JO - European Journal of Immunology
JF - European Journal of Immunology
IS - 10
ER -