Acid can have ill effect on bone health in the absence of frank clinical acidosis but affecting the bone mioneral matrix and bone cells via complex pathways botyh ascute;y and chronically. While the reaction of bone to an acid load is conserved in evolution and is adaptive, the capacity can be overwhelmed resulting in dire consequences. The preclinical an clincl evidence of the acdi effect on bone is very convincing and the clinical evidence in both association and interventiopn studies are also quite credible, The adverse effects of acid on bone is underappreoicated, under-investigated, and the potential benefits of alkali therapy is not generrally known.

Original languageEnglish (US)
Pages (from-to)381-394
Number of pages14
JournalAdvances in Chronic Kidney Disease
Issue number4
StatePublished - Jul 2022


  • Acid load
  • Acidosis
  • Alkali therapy
  • Bone

ASJC Scopus subject areas

  • Nephrology


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