Precision Medicine and PET–Computed Tomography in Pediatric Malignancies

Yasemin Sanli; Ebru Yilmaz; Rathan M. Subramaniam

doi:10.1016/j.cpet.2017.05.009

Precision Medicine and PET–Computed Tomography in Pediatric Malignancies

Yasemin Sanli, Ebru Yilmaz, Rathan M. Subramaniam

Research output: Contribution to journal › Review article › peer-review

2 Scopus citations

Abstract

Fluorine-18 fluorodeoxyglucose (¹⁸F-FDG) PET–computed tomography (CT) plays a significant role in diagnosis, staging, therapy selection, and therapy assessment of multiple pediatric malignancies and facilitating precision medicine delivery in pediatric patients. In patients with Hodgkin lymphoma, interim fludeoxyglucose ¹⁸F-FDG PET/CT is highly sensitive and specific for predicting survival and multiple trials with FDG PET/CT–based adaptive therapies are currently ongoing. It is superior to iodine-131 metaiodobenzylguanidine (¹³¹I-MIBG) scintigraphy and bone scintigraphy for detecting metastases in neuroblastoma patients and sarcoma patients. It may predict histologic differentiation and neoadjuvant therapy assessment in Wilms tumor.

Original language	English (US)
Pages (from-to)	423-435
Number of pages	13
Journal	PET Clinics
Volume	12
Issue number	4
DOIs	https://doi.org/10.1016/j.cpet.2017.05.009
State	Published - Oct 1 2017

Keywords

Pediatric malignancies
PET
PET/CT

ASJC Scopus subject areas

Radiation
Radiology Nuclear Medicine and imaging

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10.1016/j.cpet.2017.05.009

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title = "Precision Medicine and PET–Computed Tomography in Pediatric Malignancies",

abstract = "Fluorine-18 fluorodeoxyglucose (18F-FDG) PET–computed tomography (CT) plays a significant role in diagnosis, staging, therapy selection, and therapy assessment of multiple pediatric malignancies and facilitating precision medicine delivery in pediatric patients. In patients with Hodgkin lymphoma, interim fludeoxyglucose 18F-FDG PET/CT is highly sensitive and specific for predicting survival and multiple trials with FDG PET/CT–based adaptive therapies are currently ongoing. It is superior to iodine-131 metaiodobenzylguanidine (131I-MIBG) scintigraphy and bone scintigraphy for detecting metastases in neuroblastoma patients and sarcoma patients. It may predict histologic differentiation and neoadjuvant therapy assessment in Wilms tumor.",

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AU - Sanli, Yasemin

AU - Yilmaz, Ebru

AU - Subramaniam, Rathan M.

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Y1 - 2017/10/1

N2 - Fluorine-18 fluorodeoxyglucose (18F-FDG) PET–computed tomography (CT) plays a significant role in diagnosis, staging, therapy selection, and therapy assessment of multiple pediatric malignancies and facilitating precision medicine delivery in pediatric patients. In patients with Hodgkin lymphoma, interim fludeoxyglucose 18F-FDG PET/CT is highly sensitive and specific for predicting survival and multiple trials with FDG PET/CT–based adaptive therapies are currently ongoing. It is superior to iodine-131 metaiodobenzylguanidine (131I-MIBG) scintigraphy and bone scintigraphy for detecting metastases in neuroblastoma patients and sarcoma patients. It may predict histologic differentiation and neoadjuvant therapy assessment in Wilms tumor.

AB - Fluorine-18 fluorodeoxyglucose (18F-FDG) PET–computed tomography (CT) plays a significant role in diagnosis, staging, therapy selection, and therapy assessment of multiple pediatric malignancies and facilitating precision medicine delivery in pediatric patients. In patients with Hodgkin lymphoma, interim fludeoxyglucose 18F-FDG PET/CT is highly sensitive and specific for predicting survival and multiple trials with FDG PET/CT–based adaptive therapies are currently ongoing. It is superior to iodine-131 metaiodobenzylguanidine (131I-MIBG) scintigraphy and bone scintigraphy for detecting metastases in neuroblastoma patients and sarcoma patients. It may predict histologic differentiation and neoadjuvant therapy assessment in Wilms tumor.

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KW - PET

KW - PET/CT

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Precision Medicine and PET–Computed Tomography in Pediatric Malignancies

Abstract

Keywords

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