Practical, enantiospecific syntheses of 14,15-EET and leukotoxin B (vernolic acid)

J R Falck, Y. Krishna Reddy, Donovan C. Haines, Komandla Malla Reddy, U. Murali Krishna, Sandra Graham, Barbara Murry, Julian A. Peterson

Research output: Contribution to journalArticlepeer-review

22 Scopus citations


Cytochrome P450BM3 and its F87V mutant were exploited for a convenient, laboratory scale (1 mmol) preparation of 14(S),15(R)-epoxyeicosatrienoic acid [14(S),15(R)-EET] from arachidonic acid and (+)-leukotoxin B [(+)-12(S),13(R)-vernolic acid] from linoleic acid, respectively. Their enantiomers were accessed via a four-step chemical inversion.

Original languageEnglish (US)
Pages (from-to)4131-4133
Number of pages3
JournalTetrahedron Letters
Issue number25
StatePublished - Jun 18 2001


  • Asymmetric synthesis
  • Biosynthesis
  • Eicosanoids
  • Epoxides
  • Inversion reactions

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry


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