Potential of [11C]TMSX for the evaluation of adenosine A 2A receptors in the skeletal muscle by positron emission tomography

Kiichi Ishiwata; Masaki Mizuno; Yuichi Kimura; Kazunori Kawamura; Keiichi Oda; Toru Sasaki; Yoshio Nakamura; Isao Muraoka; Kenji Ishii

doi:10.1016/j.nucmedbio.2004.06.003

Potential of [¹¹C]TMSX for the evaluation of adenosine A _2A receptors in the skeletal muscle by positron emission tomography

Kiichi Ishiwata, Masaki Mizuno, Yuichi Kimura, Kazunori Kawamura, Keiichi Oda, Toru Sasaki, Yoshio Nakamura, Isao Muraoka, Kenji Ishii

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

We examined the potential of [7-methyl-¹¹C]-(E)-8-(3,4,5- trimethoxystyryl)-1,3,7-trimethylxanthine ([¹¹C]TMSX) for the assessment of adenosine A_2A receptors in muscle. In rodents, specific binding of [¹¹C]TMSX was observed in muscle and heart by blockade with A_2A-selective CSC and non-selective theophylline, but not with A₁-selective DPCPX. Swimming exercise fluctuated radioligand-receptor binding in these tissues. In a PET study of two subjects, theophylline-infusion slightly deceased the distribution volume of [¹¹C]TMSX in the heart (20% reduction) and muscle (10% reduction), which suggested the specific binding.

Original language	English (US)
Pages (from-to)	949-956
Number of pages	8
Journal	Nuclear Medicine and Biology
Volume	31
Issue number	7
DOIs	https://doi.org/10.1016/j.nucmedbio.2004.06.003
State	Published - Oct 2004

Keywords

Adenosine A receptor
Human
Muscle
Positron emission tomography
[C]TMSX

ASJC Scopus subject areas

Molecular Medicine
Radiology Nuclear Medicine and imaging
Cancer Research

Access to Document

10.1016/j.nucmedbio.2004.06.003

Cite this

@article{96f7234d576a4b19910aa19f4117669c,

title = "Potential of [11C]TMSX for the evaluation of adenosine A 2A receptors in the skeletal muscle by positron emission tomography",

abstract = "We examined the potential of [7-methyl-11C]-(E)-8-(3,4,5- trimethoxystyryl)-1,3,7-trimethylxanthine ([11C]TMSX) for the assessment of adenosine A2A receptors in muscle. In rodents, specific binding of [11C]TMSX was observed in muscle and heart by blockade with A2A-selective CSC and non-selective theophylline, but not with A1-selective DPCPX. Swimming exercise fluctuated radioligand-receptor binding in these tissues. In a PET study of two subjects, theophylline-infusion slightly deceased the distribution volume of [11C]TMSX in the heart (20% reduction) and muscle (10% reduction), which suggested the specific binding.",

keywords = "Adenosine A receptor, Human, Muscle, Positron emission tomography, [C]TMSX",

author = "Kiichi Ishiwata and Masaki Mizuno and Yuichi Kimura and Kazunori Kawamura and Keiichi Oda and Toru Sasaki and Yoshio Nakamura and Isao Muraoka and Kenji Ishii",

note = "Funding Information: This work was supported by the Grant-in-Aid for Scientific Research (B) No. 16390348 of the Japan Society for the Promotion of Science. The authors thank Ms. Miyoko Ando for her care of the subjects during PET measurement.",

year = "2004",

month = oct,

doi = "10.1016/j.nucmedbio.2004.06.003",

language = "English (US)",

volume = "31",

pages = "949--956",

journal = "Nuclear Medicine and Biology",

issn = "0969-8051",

publisher = "Elsevier Inc.",

number = "7",

}

TY - JOUR

T1 - Potential of [11C]TMSX for the evaluation of adenosine A 2A receptors in the skeletal muscle by positron emission tomography

AU - Ishiwata, Kiichi

AU - Mizuno, Masaki

AU - Kimura, Yuichi

AU - Kawamura, Kazunori

AU - Oda, Keiichi

AU - Sasaki, Toru

AU - Nakamura, Yoshio

AU - Muraoka, Isao

AU - Ishii, Kenji

N1 - Funding Information: This work was supported by the Grant-in-Aid for Scientific Research (B) No. 16390348 of the Japan Society for the Promotion of Science. The authors thank Ms. Miyoko Ando for her care of the subjects during PET measurement.

PY - 2004/10

Y1 - 2004/10

N2 - We examined the potential of [7-methyl-11C]-(E)-8-(3,4,5- trimethoxystyryl)-1,3,7-trimethylxanthine ([11C]TMSX) for the assessment of adenosine A2A receptors in muscle. In rodents, specific binding of [11C]TMSX was observed in muscle and heart by blockade with A2A-selective CSC and non-selective theophylline, but not with A1-selective DPCPX. Swimming exercise fluctuated radioligand-receptor binding in these tissues. In a PET study of two subjects, theophylline-infusion slightly deceased the distribution volume of [11C]TMSX in the heart (20% reduction) and muscle (10% reduction), which suggested the specific binding.

AB - We examined the potential of [7-methyl-11C]-(E)-8-(3,4,5- trimethoxystyryl)-1,3,7-trimethylxanthine ([11C]TMSX) for the assessment of adenosine A2A receptors in muscle. In rodents, specific binding of [11C]TMSX was observed in muscle and heart by blockade with A2A-selective CSC and non-selective theophylline, but not with A1-selective DPCPX. Swimming exercise fluctuated radioligand-receptor binding in these tissues. In a PET study of two subjects, theophylline-infusion slightly deceased the distribution volume of [11C]TMSX in the heart (20% reduction) and muscle (10% reduction), which suggested the specific binding.

KW - Adenosine A receptor

KW - Human

KW - Muscle

KW - Positron emission tomography

KW - [C]TMSX

UR - http://www.scopus.com/inward/record.url?scp=4644330956&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=4644330956&partnerID=8YFLogxK

U2 - 10.1016/j.nucmedbio.2004.06.003

DO - 10.1016/j.nucmedbio.2004.06.003

M3 - Article

C2 - 15464397

AN - SCOPUS:4644330956

SN - 0969-8051

VL - 31

SP - 949

EP - 956

JO - Nuclear Medicine and Biology

JF - Nuclear Medicine and Biology

IS - 7

ER -