TY - JOUR
T1 - Posttraumatic contrast-induced acute kidney injury
T2 - Minimal consequences or significant threat?
AU - Matsushima, Kazuhide
AU - Peng, Monica
AU - Schaefer, Eric W.
AU - Pruitt, Jeffrey H.
AU - Kashuk, Jeffry L.
AU - Frankel, Heidi L.
PY - 2011/2
Y1 - 2011/2
N2 - Background: Recent enthusiasm for the use of iodinated contrast media and progressive adaption of modern imaging techniques suggests an increased risk of contrast-induced acute kidney injury (CIAKI) in trauma patients. We hypothesized that CIAKI incidence would be higher than that previously reported. Methods: A 1-year retrospective review of our prospective database was performed. Low-osmolar, nonionic, iodinated intravascular (IV) contrast was used exclusively. CIAKI was defined as serum creatinine >0.5 mg/dL, or >25% increase from baseline within 72 hours of admission. The association between CIAKI and risk factors was explored. Results: Of 3,775 patients, 1,184 (31.4%) received IV contrast and had baseline and follow-up serum creatinine. Median age was 38 years (range, 18-95 years) and median Injury Severity Score (ISS) was 16. A total of 8% of patients had history of diabetes mellitus. CIAKI was identified in 78 (6.6%). One patient required long-term hemodialysis. In univariable analysis, age >65 years (p = 0.01), history of diabetes mellitus (p = 0.01), initial creatinine >1.5 mg/dL (p = 0.01), ISS ≥16 (p = 0.04), and initial systolic blood pressure <90 mm Hg (p = 0.01) were identified as risk factors for CIAKI. Of note, no association with the dose of IV contrast ≥250 mL and CIAKI was identified (p = 0.95). A multiple logistic regression model identified higher age, male gender, systolic blood pressure <90 mm Hg, and higher ISS as risk factors for CIAKI. In-hospital mortality was significantly higher in the CIAKI group (9.0% vs. 3.2%, p = 0.02). After adjusting for covariates, CIAKI was not significantly associated with in-hospital mortality. Conclusion: Current trauma management places patients at substantial risk for CIAKI, and risk stratification can be assessed by common clinical criteria. IV contrast dose alone is not an independent associated risk factor. How these data would be extrapolated to an older cohort remains to be determined.
AB - Background: Recent enthusiasm for the use of iodinated contrast media and progressive adaption of modern imaging techniques suggests an increased risk of contrast-induced acute kidney injury (CIAKI) in trauma patients. We hypothesized that CIAKI incidence would be higher than that previously reported. Methods: A 1-year retrospective review of our prospective database was performed. Low-osmolar, nonionic, iodinated intravascular (IV) contrast was used exclusively. CIAKI was defined as serum creatinine >0.5 mg/dL, or >25% increase from baseline within 72 hours of admission. The association between CIAKI and risk factors was explored. Results: Of 3,775 patients, 1,184 (31.4%) received IV contrast and had baseline and follow-up serum creatinine. Median age was 38 years (range, 18-95 years) and median Injury Severity Score (ISS) was 16. A total of 8% of patients had history of diabetes mellitus. CIAKI was identified in 78 (6.6%). One patient required long-term hemodialysis. In univariable analysis, age >65 years (p = 0.01), history of diabetes mellitus (p = 0.01), initial creatinine >1.5 mg/dL (p = 0.01), ISS ≥16 (p = 0.04), and initial systolic blood pressure <90 mm Hg (p = 0.01) were identified as risk factors for CIAKI. Of note, no association with the dose of IV contrast ≥250 mL and CIAKI was identified (p = 0.95). A multiple logistic regression model identified higher age, male gender, systolic blood pressure <90 mm Hg, and higher ISS as risk factors for CIAKI. In-hospital mortality was significantly higher in the CIAKI group (9.0% vs. 3.2%, p = 0.02). After adjusting for covariates, CIAKI was not significantly associated with in-hospital mortality. Conclusion: Current trauma management places patients at substantial risk for CIAKI, and risk stratification can be assessed by common clinical criteria. IV contrast dose alone is not an independent associated risk factor. How these data would be extrapolated to an older cohort remains to be determined.
KW - Contrast-induced acute kidney injury
KW - Intravascular contrast
KW - Risk factor
KW - Trauma patient
UR - http://www.scopus.com/inward/record.url?scp=79951592554&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=79951592554&partnerID=8YFLogxK
U2 - 10.1097/TA.0b013e3182095fa6
DO - 10.1097/TA.0b013e3182095fa6
M3 - Article
C2 - 21307743
AN - SCOPUS:79951592554
SN - 0022-5282
VL - 70
SP - 415
EP - 420
JO - Journal of Trauma - Injury, Infection and Critical Care
JF - Journal of Trauma - Injury, Infection and Critical Care
IS - 2
ER -