Postprandial lipemia and chylomicron clearance in athletes and in sedentary men

J. C. Cohen, T. D. Noakes, A. J S Benade

Research output: Contribution to journalArticlepeer-review

79 Scopus citations


To examine the effects of exercise on postprandial serum triglyceride (TG) metabolism, we measured oral and intravenous fat tolerance and chylomicron-TG half-life in highly trained endurance athletes and in a sedentary control group matched for body weight and fasting serum TG concentration. Postprandial lipemia was lower in athletes after meals containing 40 g fat (1.5 ± 0.7 vs 2.6 ± 1.5 mmol·L-1·8 h-1, p < 0.001) or 140 g fat (2.5 ± 1.2 vs 6.1 ± 1.9 mmol·L-1·8 h-1, p < 0.001). The disappearance of an intravenous bolus of Intralipid® was faster in athletes (5.4 ± 1.2%/min) than in sedentary men (4.3 ± 0.8%/min, p < 0.01). The half-life of chylomicron-TG was shorter in athletes (3.0 ± 0.8 min) than in sedentary men (4.0 ± 1.0 min, p < 0.05). These findings indicate that chronic exercise decreases postprandial lipemia by reducing chylomicron-TG's half-life. This effect is due partly to reduced fasting serum TG pool size and partly to a direct effect of exercise on the serum TG removal system.

Original languageEnglish (US)
Pages (from-to)443-447
Number of pages5
JournalAmerican Journal of Clinical Nutrition
Issue number3
StatePublished - Jan 1 1989

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics


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