Postchemotherapy surgery for germ cell tumors-what have we learned in 35 years?

Stephen B. Riggs, Earl F. Burgess, Kris E. Gaston, Caroline A. Merwarth, Derek Raghavan

Research output: Contribution to journalArticlepeer-review

16 Scopus citations


Postchemotherapy surgery for advanced testicular cancer has evolved over the last couple of decades. Patients with nonseminomatous germ cell tumors and residual retroperitoneal mass ≥1 cm should undergo postchemotherapy retroperitoneal lymph node dissection (RPLND). For seminoma, RPLND isconsidered inthose patients with masses ≥3cmthat are also positron emission tomography positive. Masses that occur outside of the retroperitoneum should be completely resected with the possible exception of bilateral lung masses when resection of the first mass shows necrosis. The role of surgery in patients with extragonadal germ cell tumors is most vital in those with primary mediastinal nonseminomatous germ cell tumors. Importantly, patient selection, surgical planning, and consideration of referral to centers with this expertise are important to optimize success.

Original languageEnglish (US)
Pages (from-to)498-506
Number of pages9
Issue number5
StatePublished - 2014
Externally publishedYes


  • Germ cell tumor
  • Nonseminoma
  • Postchemotherapy retroperitoneal lymph node dissection
  • Retroperitoneal lymph node dissection
  • Seminoma
  • Testicular cancer

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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