Post-infectious neurological disorders

Kyle M. Blackburn; Cynthia Wang

doi:10.1177/1756286420952901

Post-infectious neurological disorders

Kyle M. Blackburn, Cynthia Wang

Research output: Contribution to journal › Review article › peer-review

30 Scopus citations

Abstract

A multitude of environmental factors can result in breakdown of immune tolerance in susceptible hosts. Infectious pathogens are among the most important environmental triggers in the pathogenesis of autoimmunity. Certain autoimmune disorders have a strong association with specific infections. Several neurological autoimmune disorders are thought to occur through post-infectious mechanisms. In this review, we discuss the proposed mechanisms underlying pathogen-induced autoimmunity, and highlight the clinical presentation and treatment of several post-infectious autoimmune neurological disorders. We also highlight post-infectious neurological disorders in the setting of recent outbreaks.

Original language	English (US)
Journal	Therapeutic Advances in Neurological Disorders
Volume	13
DOIs	https://doi.org/10.1177/1756286420952901
State	Published - 2020

Keywords

Acute Disseminated Encephalomyelitis
Autoimmune Encephalitis
Guillain-Barre syndrome
Neuroimmunology

ASJC Scopus subject areas

Pharmacology
Neurology
Clinical Neurology

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10.1177/1756286420952901

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title = "Post-infectious neurological disorders",

abstract = "A multitude of environmental factors can result in breakdown of immune tolerance in susceptible hosts. Infectious pathogens are among the most important environmental triggers in the pathogenesis of autoimmunity. Certain autoimmune disorders have a strong association with specific infections. Several neurological autoimmune disorders are thought to occur through post-infectious mechanisms. In this review, we discuss the proposed mechanisms underlying pathogen-induced autoimmunity, and highlight the clinical presentation and treatment of several post-infectious autoimmune neurological disorders. We also highlight post-infectious neurological disorders in the setting of recent outbreaks.",

keywords = "Acute Disseminated Encephalomyelitis, Autoimmune Encephalitis, Guillain-Barre syndrome, Neuroimmunology",

author = "Blackburn, {Kyle M.} and Cynthia Wang",

note = "Funding Information: The fellowships of K.B and C.W. were funded by the Siegel Rare Neuroimmune Association. Publisher Copyright: {\textcopyright} The Author(s), 2020.",

year = "2020",

doi = "10.1177/1756286420952901",

language = "English (US)",

volume = "13",

journal = "Therapeutic Advances in Neurological Disorders",

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T1 - Post-infectious neurological disorders

AU - Blackburn, Kyle M.

AU - Wang, Cynthia

N1 - Funding Information: The fellowships of K.B and C.W. were funded by the Siegel Rare Neuroimmune Association. Publisher Copyright: © The Author(s), 2020.

PY - 2020

Y1 - 2020

N2 - A multitude of environmental factors can result in breakdown of immune tolerance in susceptible hosts. Infectious pathogens are among the most important environmental triggers in the pathogenesis of autoimmunity. Certain autoimmune disorders have a strong association with specific infections. Several neurological autoimmune disorders are thought to occur through post-infectious mechanisms. In this review, we discuss the proposed mechanisms underlying pathogen-induced autoimmunity, and highlight the clinical presentation and treatment of several post-infectious autoimmune neurological disorders. We also highlight post-infectious neurological disorders in the setting of recent outbreaks.

AB - A multitude of environmental factors can result in breakdown of immune tolerance in susceptible hosts. Infectious pathogens are among the most important environmental triggers in the pathogenesis of autoimmunity. Certain autoimmune disorders have a strong association with specific infections. Several neurological autoimmune disorders are thought to occur through post-infectious mechanisms. In this review, we discuss the proposed mechanisms underlying pathogen-induced autoimmunity, and highlight the clinical presentation and treatment of several post-infectious autoimmune neurological disorders. We also highlight post-infectious neurological disorders in the setting of recent outbreaks.

KW - Acute Disseminated Encephalomyelitis

KW - Autoimmune Encephalitis

KW - Guillain-Barre syndrome

KW - Neuroimmunology

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DO - 10.1177/1756286420952901

M3 - Review article

C2 - 32944082

AN - SCOPUS:85090051339

SN - 1756-2856

VL - 13

JO - Therapeutic Advances in Neurological Disorders

JF - Therapeutic Advances in Neurological Disorders

ER -

Post-infectious neurological disorders

Abstract

Keywords

ASJC Scopus subject areas

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