TY - JOUR
T1 - Possible lower rate of chronic ITP after IVIG for acute childhood ITP an analysis from registry i of the Intercontinental Cooperative ITP Study Group (ICIS)
AU - Tamminga, Rienk
AU - Berchtold, Willi
AU - Bruin, Marrie
AU - Buchanan, George R.
AU - Kühne, Thomas
N1 - Copyright:
Copyright 2011 Elsevier B.V., All rights reserved.
PY - 2009/7
Y1 - 2009/7
N2 - In children, one-third of immune thrombocytopenic purpura (ITP) patients follow a chronic course. The present study investigated whether treatment with intravenous immunoglobulin (IVIG) at the time of diagnosis of ITP is of prognostic significance, using data from 1984 children entered in Registry I of the Intercontinental Cooperative ITP Study Group. A matched pairs analysis compared children with thrombocytopenia (platelet count <150 × 10 9/l) 6 months following diagnosis with children whose platelet count was normal 6 months after diagnosis. It was found that children initially treated with IVIG were more likely to have a normal platelet count 6 months after diagnosis than children not receiving IVIG (odds ratio 1·81; 95% confidence interval: 1·25-2·64). This result was independent of age, gender, country of origin, platelet count at diagnosis or infection preceding the diagnosis of ITP. In a similar analysis, comparing children with a platelet count <50 × 109/l 6 months after diagnosis with children whose platelet count was ≥50 × 109/l at that time point, the former group was less often treated with IVIG than with steroids (P = 0·02). Prospective studies are required to further explore this potential effect of IVIG.
AB - In children, one-third of immune thrombocytopenic purpura (ITP) patients follow a chronic course. The present study investigated whether treatment with intravenous immunoglobulin (IVIG) at the time of diagnosis of ITP is of prognostic significance, using data from 1984 children entered in Registry I of the Intercontinental Cooperative ITP Study Group. A matched pairs analysis compared children with thrombocytopenia (platelet count <150 × 10 9/l) 6 months following diagnosis with children whose platelet count was normal 6 months after diagnosis. It was found that children initially treated with IVIG were more likely to have a normal platelet count 6 months after diagnosis than children not receiving IVIG (odds ratio 1·81; 95% confidence interval: 1·25-2·64). This result was independent of age, gender, country of origin, platelet count at diagnosis or infection preceding the diagnosis of ITP. In a similar analysis, comparing children with a platelet count <50 × 109/l 6 months after diagnosis with children whose platelet count was ≥50 × 109/l at that time point, the former group was less often treated with IVIG than with steroids (P = 0·02). Prospective studies are required to further explore this potential effect of IVIG.
KW - Childhood
KW - Chronic immune thrombocytopenic purpura
KW - Intercontinental Cooperative ITP Study Group
KW - Intravenous immunoglobulin
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U2 - 10.1111/j.1365-2141.2009.07743.x
DO - 10.1111/j.1365-2141.2009.07743.x
M3 - Article
C2 - 19466971
AN - SCOPUS:67649933232
SN - 0007-1048
VL - 146
SP - 180
EP - 184
JO - British Journal of Haematology
JF - British Journal of Haematology
IS - 2
ER -