Positive chronotropic effects of endothelin, a novel endothelium-derived vasoconstrictor peptide

Tomohisa Ishikawa; Masashi Yanagisawa; Sadao Kimura; Katsutoshi Goto; Tomoh Masaki

doi:10.1007/BF00581239

Positive chronotropic effects of endothelin, a novel endothelium-derived vasoconstrictor peptide

Tomohisa Ishikawa, Masashi Yanagisawa, Sadao Kimura, Katsutoshi Goto, Tomoh Masaki

Research output: Contribution to journal › Article › peer-review

200 Scopus citations

Abstract

Endothelin (ET) is a novel 21-amino-acid peptide isolated from the culture supernatant of porcine aortic endothelial cells, which has a potent vasoconstricting effect. It has been suggested that ET increases Ca²⁺ influx via a voltage-dependent Ca²⁺ channel. The purpose of the present study is to investigate the mode of actions of ET on the cardiac automaticity. ET increased the sinoatrial nodal rate in a dose-dependent manner on the isolated right atria of guinea pigs. The positive chronotropic effect of ET was very potent and the ED₅₀ value was 0.4 nM. These results suggest that ET is one of the most potent cardio-acceleratory substances.

Original language	English (US)
Pages (from-to)	108-110
Number of pages	3
Journal	Pflügers Archiv European Journal of Physiology
Volume	413
Issue number	1
DOIs	https://doi.org/10.1007/BF00581239
State	Published - Nov 1988

Keywords

Bay K 8644
Endothelin
Guinea pig
Positive chronotropic effect
Right atria

ASJC Scopus subject areas

Physiology
Clinical Biochemistry
Physiology (medical)

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10.1007/BF00581239

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abstract = "Endothelin (ET) is a novel 21-amino-acid peptide isolated from the culture supernatant of porcine aortic endothelial cells, which has a potent vasoconstricting effect. It has been suggested that ET increases Ca2+ influx via a voltage-dependent Ca2+ channel. The purpose of the present study is to investigate the mode of actions of ET on the cardiac automaticity. ET increased the sinoatrial nodal rate in a dose-dependent manner on the isolated right atria of guinea pigs. The positive chronotropic effect of ET was very potent and the ED50 value was 0.4 nM. These results suggest that ET is one of the most potent cardio-acceleratory substances.",

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AU - Ishikawa, Tomohisa

AU - Yanagisawa, Masashi

AU - Kimura, Sadao

AU - Goto, Katsutoshi

AU - Masaki, Tomoh

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AB - Endothelin (ET) is a novel 21-amino-acid peptide isolated from the culture supernatant of porcine aortic endothelial cells, which has a potent vasoconstricting effect. It has been suggested that ET increases Ca2+ influx via a voltage-dependent Ca2+ channel. The purpose of the present study is to investigate the mode of actions of ET on the cardiac automaticity. ET increased the sinoatrial nodal rate in a dose-dependent manner on the isolated right atria of guinea pigs. The positive chronotropic effect of ET was very potent and the ED50 value was 0.4 nM. These results suggest that ET is one of the most potent cardio-acceleratory substances.

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Positive chronotropic effects of endothelin, a novel endothelium-derived vasoconstrictor peptide

Abstract

Keywords

ASJC Scopus subject areas

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