Polymeric PARACEST agents for enhancing MRI contrast sensitivity

Yunkou Wu; Youfu Zhou; Olivier Ouari; Mark Woods; Piyu Zhao; Todd C. Soesbe; Garry E. Kiefer; A. Dean Sherry

doi:10.1021/ja805775u

Polymeric PARACEST agents for enhancing MRI contrast sensitivity

Yunkou Wu, Youfu Zhou, Olivier Ouari, Mark Woods, Piyu Zhao, Todd C. Soesbe, Garry E. Kiefer, A. Dean Sherry

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61 Scopus citations

Abstract

Linear polymers of PARACEST agents were prepared by using classical free radical chain polymerization conditions. The Eu³⁺-polymers exhibited similar intermediate-to-slow water exchange and CEST characteristics as the Eu³⁺-monomers. This provided an avenue to lower the detection limit of these imaging agents substantially and makes them potentially useful as MRI sensors for molecular imaging.

Original language	English (US)
Pages (from-to)	13854-13855
Number of pages	2
Journal	Journal of the American Chemical Society
Volume	130
Issue number	42
DOIs	https://doi.org/10.1021/ja805775u
State	Published - Oct 22 2008

ASJC Scopus subject areas

Catalysis
Chemistry(all)
Biochemistry
Colloid and Surface Chemistry

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10.1021/ja805775u

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title = "Polymeric PARACEST agents for enhancing MRI contrast sensitivity",

abstract = "Linear polymers of PARACEST agents were prepared by using classical free radical chain polymerization conditions. The Eu3+-polymers exhibited similar intermediate-to-slow water exchange and CEST characteristics as the Eu3+-monomers. This provided an avenue to lower the detection limit of these imaging agents substantially and makes them potentially useful as MRI sensors for molecular imaging.",

author = "Yunkou Wu and Youfu Zhou and Olivier Ouari and Mark Woods and Piyu Zhao and Soesbe, {Todd C.} and Kiefer, {Garry E.} and Sherry, {A. Dean}",

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AU - Wu, Yunkou

AU - Zhou, Youfu

AU - Ouari, Olivier

AU - Woods, Mark

AU - Zhao, Piyu

AU - Soesbe, Todd C.

AU - Kiefer, Garry E.

AU - Sherry, A. Dean

PY - 2008/10/22

Y1 - 2008/10/22

N2 - Linear polymers of PARACEST agents were prepared by using classical free radical chain polymerization conditions. The Eu3+-polymers exhibited similar intermediate-to-slow water exchange and CEST characteristics as the Eu3+-monomers. This provided an avenue to lower the detection limit of these imaging agents substantially and makes them potentially useful as MRI sensors for molecular imaging.

AB - Linear polymers of PARACEST agents were prepared by using classical free radical chain polymerization conditions. The Eu3+-polymers exhibited similar intermediate-to-slow water exchange and CEST characteristics as the Eu3+-monomers. This provided an avenue to lower the detection limit of these imaging agents substantially and makes them potentially useful as MRI sensors for molecular imaging.

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Polymeric PARACEST agents for enhancing MRI contrast sensitivity

Abstract

ASJC Scopus subject areas

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