Polymeric nanoparticles for drug delivery to the central nervous system

Toral Patel, Jiangbing Zhou, Joseph M. Piepmeier, W. Mark Saltzman

Research output: Contribution to journalReview articlepeer-review

380 Scopus citations


The central nervous system (CNS) poses a unique challenge for drug delivery. The blood-brain barrier significantly hinders the passage of systemically delivered therapeutics and the brain extracellular matrix limits the distribution and longevity of locally delivered agents. Polymeric nanoparticles represent a promising solution to these problems. Over the past 40. years, substantial research efforts have demonstrated that polymeric nanoparticles can be engineered for effective systemic and local delivery of therapeutics to the CNS. Moreover, many of the polymers used in nanoparticle fabrication are both biodegradable and biocompatible, thereby increasing the clinical utility of this strategy. Here, we review the major advances in the development of polymeric nanoparticles for drug delivery to the CNS.

Original languageEnglish (US)
Pages (from-to)701-705
Number of pages5
JournalAdvanced Drug Delivery Reviews
Issue number7
StatePublished - May 15 2012


  • Blood-brain barrier
  • Brain
  • Convection-enhanced delivery
  • Nanoparticle
  • Polymer

ASJC Scopus subject areas

  • Pharmaceutical Science


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