Poly(L-lysine)-graft-dextran copolymer remarkably promotes pyrimidine- motif triplex formation at neutral pH: Thermodynamic and kinetic studies

H. Torigoe; A. Ferdous; H. Watanabe; T. Akaike; A. Maruyama

doi:10.1080/07328319908044812

Poly(L-lysine)-graft-dextran copolymer remarkably promotes pyrimidine- motif triplex formation at neutral pH: Thermodynamic and kinetic studies

H. Torigoe, A. Ferdous, H. Watanabe, T. Akaike, A. Maruyama

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

The binding constant of a homopyrimidine oligonucleotide with its target duplex for the pyrimidine-motif triplex formation at neutral pH was analyzed and found to be remarkably higher in the presence of the poly (L-lysine)- graft-dextran copolymer than that without any triplex stabilizer or in the presence of spermine. The promoting effect mainly results from the considerable increase in the association rate constant.

Original language	English (US)
Pages (from-to)	1655-1656
Number of pages	2
Journal	Nucleosides and Nucleotides
Volume	18
Issue number	6-7
DOIs	https://doi.org/10.1080/07328319908044812
State	Published - Jan 1 1999

ASJC Scopus subject areas

Biochemistry
Genetics

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10.1080/07328319908044812

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T1 - Poly(L-lysine)-graft-dextran copolymer remarkably promotes pyrimidine- motif triplex formation at neutral pH

T2 - Thermodynamic and kinetic studies

AU - Torigoe, H.

AU - Ferdous, A.

AU - Watanabe, H.

AU - Akaike, T.

AU - Maruyama, A.

PY - 1999/1/1

Y1 - 1999/1/1

N2 - The binding constant of a homopyrimidine oligonucleotide with its target duplex for the pyrimidine-motif triplex formation at neutral pH was analyzed and found to be remarkably higher in the presence of the poly (L-lysine)- graft-dextran copolymer than that without any triplex stabilizer or in the presence of spermine. The promoting effect mainly results from the considerable increase in the association rate constant.

AB - The binding constant of a homopyrimidine oligonucleotide with its target duplex for the pyrimidine-motif triplex formation at neutral pH was analyzed and found to be remarkably higher in the presence of the poly (L-lysine)- graft-dextran copolymer than that without any triplex stabilizer or in the presence of spermine. The promoting effect mainly results from the considerable increase in the association rate constant.

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ER -

Poly(L-lysine)-graft-dextran copolymer remarkably promotes pyrimidine- motif triplex formation at neutral pH: Thermodynamic and kinetic studies

Abstract

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