Plasma ropivacaine levels during awake intracranial surgery

Paul B. Audu, Chuck Wilkerson, Richard Bartkowski, Kevin Gingrich, Eugene Viscusi, David Andrews

Research output: Contribution to journalArticlepeer-review

14 Scopus citations


Plasma ropivacaine levels produced by routine scalp infiltration for field block were assayed in eight patients undergoing awake intracranial surgery. Levels peaked within approximately 13 minutes, indicating rapid systemic absorption of ropivacaine. Potentially toxic plasma drug levels were achieved in three of eight patients, although no untoward effects attributable to elevated levels of ropivacaine were observed. Clinical vigilance is indicated during scalp infiltration with ropivacaine.

Original languageEnglish (US)
Pages (from-to)153-155
Number of pages3
JournalJournal of Neurosurgical Anesthesiology
Issue number3
StatePublished - Jul 1 2005


  • Awake craniotomy
  • Local anesthetic toxicity
  • Ropivacaine

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology
  • Anesthesiology and Pain Medicine


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