Plasma ropivacaine levels during awake intracranial surgery

Paul B. Audu; Chuck Wilkerson; Richard Bartkowski; Kevin Gingrich; Eugene Viscusi; David Andrews

doi:10.1097/01.ana.0000167446.56839.a4

Plasma ropivacaine levels during awake intracranial surgery

Paul B. Audu, Chuck Wilkerson, Richard Bartkowski, Kevin Gingrich, Eugene Viscusi, David Andrews

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

Plasma ropivacaine levels produced by routine scalp infiltration for field block were assayed in eight patients undergoing awake intracranial surgery. Levels peaked within approximately 13 minutes, indicating rapid systemic absorption of ropivacaine. Potentially toxic plasma drug levels were achieved in three of eight patients, although no untoward effects attributable to elevated levels of ropivacaine were observed. Clinical vigilance is indicated during scalp infiltration with ropivacaine.

Original language	English (US)
Pages (from-to)	153-155
Number of pages	3
Journal	Journal of Neurosurgical Anesthesiology
Volume	17
Issue number	3
DOIs	https://doi.org/10.1097/01.ana.0000167446.56839.a4
State	Published - Jul 1 2005

Keywords

Awake craniotomy
Local anesthetic toxicity
Ropivacaine

ASJC Scopus subject areas

Surgery
Clinical Neurology
Anesthesiology and Pain Medicine

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10.1097/01.ana.0000167446.56839.a4

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abstract = "Plasma ropivacaine levels produced by routine scalp infiltration for field block were assayed in eight patients undergoing awake intracranial surgery. Levels peaked within approximately 13 minutes, indicating rapid systemic absorption of ropivacaine. Potentially toxic plasma drug levels were achieved in three of eight patients, although no untoward effects attributable to elevated levels of ropivacaine were observed. Clinical vigilance is indicated during scalp infiltration with ropivacaine.",

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AU - Audu, Paul B.

AU - Wilkerson, Chuck

AU - Bartkowski, Richard

AU - Gingrich, Kevin

AU - Viscusi, Eugene

AU - Andrews, David

PY - 2005/7/1

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N2 - Plasma ropivacaine levels produced by routine scalp infiltration for field block were assayed in eight patients undergoing awake intracranial surgery. Levels peaked within approximately 13 minutes, indicating rapid systemic absorption of ropivacaine. Potentially toxic plasma drug levels were achieved in three of eight patients, although no untoward effects attributable to elevated levels of ropivacaine were observed. Clinical vigilance is indicated during scalp infiltration with ropivacaine.

AB - Plasma ropivacaine levels produced by routine scalp infiltration for field block were assayed in eight patients undergoing awake intracranial surgery. Levels peaked within approximately 13 minutes, indicating rapid systemic absorption of ropivacaine. Potentially toxic plasma drug levels were achieved in three of eight patients, although no untoward effects attributable to elevated levels of ropivacaine were observed. Clinical vigilance is indicated during scalp infiltration with ropivacaine.

KW - Awake craniotomy

KW - Local anesthetic toxicity

KW - Ropivacaine

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Plasma ropivacaine levels during awake intracranial surgery

Abstract

Keywords

ASJC Scopus subject areas

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