Placental transfer of cefoperazone and sulbactam in the isolated in vitro perfused human placenta

Stephen J. Fortunato; Roger E. Bawdon; Michel Baum

doi:10.1016/S0002-9378(88)80188-1

Placental transfer of cefoperazone and sulbactam in the isolated in vitro perfused human placenta

Stephen J. Fortunato, Roger E. Bawdon, Michel Baum

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

The transfer of cefoperazone and sulbactam across the human placenta was studied qualitatively and quantitatively with the isolated in vitro bidirectiohally perfused human placental lobule. Clearance indexes for both cefoperazone and sulbactam were derived. The absence of active transport and facilitated diffusion were documented, implying simple diffusion as the mechanism of placental transfer for both drugs. Placental tissue levels were also studied.

Original language	English (US)
Pages (from-to)	1002-1006
Number of pages	5
Journal	American journal of obstetrics and gynecology
Volume	159
Issue number	4
DOIs	https://doi.org/10.1016/S0002-9378(88)80188-1
State	Published - Jan 1 1988

Keywords

Placenta
cefoperazone
human
in vitro placental perfusion
placental transfer
sulbactam

ASJC Scopus subject areas

Obstetrics and Gynecology

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10.1016/S0002-9378(88)80188-1

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abstract = "The transfer of cefoperazone and sulbactam across the human placenta was studied qualitatively and quantitatively with the isolated in vitro bidirectiohally perfused human placental lobule. Clearance indexes for both cefoperazone and sulbactam were derived. The absence of active transport and facilitated diffusion were documented, implying simple diffusion as the mechanism of placental transfer for both drugs. Placental tissue levels were also studied.",

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T1 - Placental transfer of cefoperazone and sulbactam in the isolated in vitro perfused human placenta

AU - Fortunato, Stephen J.

AU - Bawdon, Roger E.

AU - Baum, Michel

PY - 1988/1/1

Y1 - 1988/1/1

N2 - The transfer of cefoperazone and sulbactam across the human placenta was studied qualitatively and quantitatively with the isolated in vitro bidirectiohally perfused human placental lobule. Clearance indexes for both cefoperazone and sulbactam were derived. The absence of active transport and facilitated diffusion were documented, implying simple diffusion as the mechanism of placental transfer for both drugs. Placental tissue levels were also studied.

AB - The transfer of cefoperazone and sulbactam across the human placenta was studied qualitatively and quantitatively with the isolated in vitro bidirectiohally perfused human placental lobule. Clearance indexes for both cefoperazone and sulbactam were derived. The absence of active transport and facilitated diffusion were documented, implying simple diffusion as the mechanism of placental transfer for both drugs. Placental tissue levels were also studied.

KW - Placenta

KW - cefoperazone

KW - human

KW - in vitro placental perfusion

KW - placental transfer

KW - sulbactam

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JO - American Journal of Obstetrics and Gynecology

JF - American Journal of Obstetrics and Gynecology

IS - 4

ER -

Placental transfer of cefoperazone and sulbactam in the isolated in vitro perfused human placenta

Abstract

Keywords

ASJC Scopus subject areas

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