TY - JOUR
T1 - PKR-dependent inflammatory signals
AU - Kang, Rui
AU - Tang, Daolin
PY - 2012/10/23
Y1 - 2012/10/23
N2 - Double-stranded RNA-dependent protein kinase (PKR) is implicated in inflammation and immune dysfunction through its regulation of mitogen-activated protein kinases, interferon regulatory factor 3, nuclear factor κB, apoptosis, and autophagy pathways. A study shows that PKR is also required for the activation of inflammasomes and the subsequent release of high-mobility group box 1 (HMGB1) protein, a proinflammatory cytokine. Thus, the cell stress kinase PKR has multifaceted roles in the regulation of inflammatory immune responses, and PKR and HMGB1 are attractive targets for inflammasome-associated diseases.
AB - Double-stranded RNA-dependent protein kinase (PKR) is implicated in inflammation and immune dysfunction through its regulation of mitogen-activated protein kinases, interferon regulatory factor 3, nuclear factor κB, apoptosis, and autophagy pathways. A study shows that PKR is also required for the activation of inflammasomes and the subsequent release of high-mobility group box 1 (HMGB1) protein, a proinflammatory cytokine. Thus, the cell stress kinase PKR has multifaceted roles in the regulation of inflammatory immune responses, and PKR and HMGB1 are attractive targets for inflammasome-associated diseases.
UR - http://www.scopus.com/inward/record.url?scp=84868148599&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84868148599&partnerID=8YFLogxK
U2 - 10.1126/scisignal.2003511
DO - 10.1126/scisignal.2003511
M3 - Review article
C2 - 23092889
AN - SCOPUS:84868148599
SN - 1937-9145
VL - 5
JO - Science's STKE : signal transduction knowledge environment
JF - Science's STKE : signal transduction knowledge environment
IS - 247
M1 - pe47
ER -