TY - JOUR
T1 - PKC blockade differentially affects aversive but not appetitive gustatory memories
AU - Núñez-Jaramillo, Luis
AU - Delint-Ramirez, Ilse
AU - Bermúdez-Rattoni, Federico
N1 - Funding Information:
This work was supported by CONACyT 42657Q and DGAPA-UNAM 220706-03. We acknowledge the technical assistance of Federico Jandete, Oreste Carbajal, Francisco Pérez Eugenio and to Yahan B.A. for the text review of this manuscript.
PY - 2007/5/7
Y1 - 2007/5/7
N2 - After consumption of a new taste, there are mainly two possible outcomes for the establishment of a taste memory, either it will be aversive or safe depending on the consequences of taste consumption. It has been proposed that both types of learning share a common initial taste memory trace, which will lead to two different memory traces, safe or aversive. To study the role of PKC activity in aversive or safe taste memory formation, we administered chelerythrine, a PKC inhibitor, into the insular cortex or parietal cortex 20 min before conditioned taste aversion or attenuation of neophobia training. The results suggest that PKC activity is needed in the insular cortex for the establishment of aversive taste memory, but not for safe taste memory.
AB - After consumption of a new taste, there are mainly two possible outcomes for the establishment of a taste memory, either it will be aversive or safe depending on the consequences of taste consumption. It has been proposed that both types of learning share a common initial taste memory trace, which will lead to two different memory traces, safe or aversive. To study the role of PKC activity in aversive or safe taste memory formation, we administered chelerythrine, a PKC inhibitor, into the insular cortex or parietal cortex 20 min before conditioned taste aversion or attenuation of neophobia training. The results suggest that PKC activity is needed in the insular cortex for the establishment of aversive taste memory, but not for safe taste memory.
KW - Conditioning
KW - Insular cortex
KW - Learning
KW - Memory
KW - Recognition memory
KW - Taste
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U2 - 10.1016/j.brainres.2007.02.032
DO - 10.1016/j.brainres.2007.02.032
M3 - Article
C2 - 17382303
AN - SCOPUS:34247103228
SN - 0006-8993
VL - 1148
SP - 177
EP - 182
JO - Brain Research
JF - Brain Research
IS - 1
ER -