Pineal opsin: A nonvisual opsin expressed in chick pineal

Marianna Max, Peter J. McKinnon, Kenneth J. Seidenman, R. Keith Barrett, Meredithe L. Applebury, Joseph S. Takahashi, Robert F. Margolskee

Research output: Contribution to journalArticlepeer-review

150 Scopus citations


Pineal opsin (P-opsin), an opsin from chick that is highly expressed in pineal but is not detectable in retina, was cloned by the polymerase chain reaction. It is likely that the P-opsin lineage diverged from the retinal opsins early in opsin evolution. The amino acid sequence of P-opsin is 42 to 46 percent identical to that of the retinal opsins. P-opsin is a seven-membrane spanning, G protein-linked receptor with a Schiff-base lysine in the seventh membrane span and a Schiff-base counterion in the third membrane span. The primary sequence of P-opsin suggests that it will be maximally sensitive to ∼500-nanometer light and produce a slow and prolonged phototransduction response consistent with the nonvisual function of pineal photoreception.

Original languageEnglish (US)
Pages (from-to)1502-1506
Number of pages5
Issue number5203
StatePublished - 1995

ASJC Scopus subject areas

  • General


Dive into the research topics of 'Pineal opsin: A nonvisual opsin expressed in chick pineal'. Together they form a unique fingerprint.

Cite this