Pin1 and Alzheimer's disease

James S. Malter

doi:10.1016/j.trsl.2022.09.003

Pin1 and Alzheimer's disease

James S. Malter

Research output: Contribution to journal › Review article › peer-review

4 Scopus citations

Abstract

Alzheimer's disease (AD) is an immense and growing public health crisis. Despite over 100 years of investigation, the etiology remains elusive and therapy ineffective. Despite current gaps in knowledge, recent studies have identified dysfunction or loss-of-function of Pin1, a unique cis-trans peptidyl prolyl isomerase, as an important step in AD pathogenesis. Here I review the functionality of Pin1 and its role in neurodegeneration.

Original language	English (US)
Pages (from-to)	24-33
Number of pages	10
Journal	Translational Research
Volume	254
DOIs	https://doi.org/10.1016/j.trsl.2022.09.003
State	Published - Apr 2023

ASJC Scopus subject areas

Public Health, Environmental and Occupational Health
Physiology (medical)
Biochemistry, medical

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10.1016/j.trsl.2022.09.003

Cite this

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abstract = "Alzheimer's disease (AD) is an immense and growing public health crisis. Despite over 100 years of investigation, the etiology remains elusive and therapy ineffective. Despite current gaps in knowledge, recent studies have identified dysfunction or loss-of-function of Pin1, a unique cis-trans peptidyl prolyl isomerase, as an important step in AD pathogenesis. Here I review the functionality of Pin1 and its role in neurodegeneration.",

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AB - Alzheimer's disease (AD) is an immense and growing public health crisis. Despite over 100 years of investigation, the etiology remains elusive and therapy ineffective. Despite current gaps in knowledge, recent studies have identified dysfunction or loss-of-function of Pin1, a unique cis-trans peptidyl prolyl isomerase, as an important step in AD pathogenesis. Here I review the functionality of Pin1 and its role in neurodegeneration.

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Pin1 and Alzheimer's disease

Abstract

ASJC Scopus subject areas

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