Pilot Study of Acute Behavioral Effects of Pallidal Burst Stimulation in Parkinson's Disease

Saar Kariv; Jeong Woo Choi; Koorosh Mirpour; Ann M. Gordon; Amirreza Alijanpourotaghsara; Mohsen Benam; Ruwayd Abdalla; Sahil Chilukuri; Jianwen W. Gu; Hemant Bokil; Shruti Nanivadekar; Aryn H. Gittis; Nader Pouratian

doi:10.1002/mds.29928

Pilot Study of Acute Behavioral Effects of Pallidal Burst Stimulation in Parkinson's Disease

Saar Kariv, Jeong Woo Choi, Koorosh Mirpour, Ann M. Gordon, Amirreza Alijanpourotaghsara, Mohsen Benam, Ruwayd Abdalla, Sahil Chilukuri, Jianwen W. Gu, Hemant Bokil, Shruti Nanivadekar, Aryn H. Gittis, Nader Pouratian

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

Background: Burst-patterned pallidal deep brain stimulation (DBS) in an animal model of Parkinson's disease (PD) yields significantly prolonged therapeutic benefit compared to conventional continuous DBS, but its value in patients remains unclear. Objectives: The aims were to evaluate the safety and tolerability of acute (<2 hours) burst DBS in PD patients and to evaluate preliminary clinical effectiveness relative to conventional DBS. Methods: Six PD patients were studied with DBS OFF, conventional DBS, and burst DBS. Unified Parkinson's Disease Rating Scale III (UPDRS-III) and proactive inhibition (using stop-signal task) were evaluated for each condition. Results: Burst and conventional DBS were equally tolerated without significant adverse events. Both stimulation patterns provided equivalent significant UPDRS-III reduction and increased proactive inhibition relative to DBS OFF. Conclusions: This pilot study supports the safety and tolerability of burst DBS, with acute effects similar to conventional DBS. Further larger-scale studies are warranted given the potential benefits of burst DBS due to decreased total energy delivery.

Original language	English (US)
Pages (from-to)	1873-1877
Number of pages	5
Journal	Movement Disorders
Volume	39
Issue number	10
DOIs	https://doi.org/10.1002/mds.29928
State	Published - Oct 2024

Keywords

Parkinson's disease
burst stimulation
deep brain stimulation

ASJC Scopus subject areas

Neurology
Clinical Neurology

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title = "Pilot Study of Acute Behavioral Effects of Pallidal Burst Stimulation in Parkinson's Disease",

abstract = "Background: Burst-patterned pallidal deep brain stimulation (DBS) in an animal model of Parkinson's disease (PD) yields significantly prolonged therapeutic benefit compared to conventional continuous DBS, but its value in patients remains unclear. Objectives: The aims were to evaluate the safety and tolerability of acute (<2 hours) burst DBS in PD patients and to evaluate preliminary clinical effectiveness relative to conventional DBS. Methods: Six PD patients were studied with DBS OFF, conventional DBS, and burst DBS. Unified Parkinson's Disease Rating Scale III (UPDRS-III) and proactive inhibition (using stop-signal task) were evaluated for each condition. Results: Burst and conventional DBS were equally tolerated without significant adverse events. Both stimulation patterns provided equivalent significant UPDRS-III reduction and increased proactive inhibition relative to DBS OFF. Conclusions: This pilot study supports the safety and tolerability of burst DBS, with acute effects similar to conventional DBS. Further larger-scale studies are warranted given the potential benefits of burst DBS due to decreased total energy delivery.",

keywords = "Parkinson's disease, burst stimulation, deep brain stimulation",

author = "Saar Kariv and Choi, {Jeong Woo} and Koorosh Mirpour and Gordon, {Ann M.} and Amirreza Alijanpourotaghsara and Mohsen Benam and Ruwayd Abdalla and Sahil Chilukuri and Gu, {Jianwen W.} and Hemant Bokil and Shruti Nanivadekar and Gittis, {Aryn H.} and Nader Pouratian",

note = "Publisher Copyright: {\textcopyright} 2024 The Author(s). Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.",

year = "2024",

month = oct,

doi = "10.1002/mds.29928",

language = "English (US)",

volume = "39",

pages = "1873--1877",

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T1 - Pilot Study of Acute Behavioral Effects of Pallidal Burst Stimulation in Parkinson's Disease

AU - Kariv, Saar

AU - Choi, Jeong Woo

AU - Mirpour, Koorosh

AU - Gordon, Ann M.

AU - Alijanpourotaghsara, Amirreza

AU - Benam, Mohsen

AU - Abdalla, Ruwayd

AU - Chilukuri, Sahil

AU - Gu, Jianwen W.

AU - Bokil, Hemant

AU - Nanivadekar, Shruti

AU - Gittis, Aryn H.

AU - Pouratian, Nader

PY - 2024/10

Y1 - 2024/10

N2 - Background: Burst-patterned pallidal deep brain stimulation (DBS) in an animal model of Parkinson's disease (PD) yields significantly prolonged therapeutic benefit compared to conventional continuous DBS, but its value in patients remains unclear. Objectives: The aims were to evaluate the safety and tolerability of acute (<2 hours) burst DBS in PD patients and to evaluate preliminary clinical effectiveness relative to conventional DBS. Methods: Six PD patients were studied with DBS OFF, conventional DBS, and burst DBS. Unified Parkinson's Disease Rating Scale III (UPDRS-III) and proactive inhibition (using stop-signal task) were evaluated for each condition. Results: Burst and conventional DBS were equally tolerated without significant adverse events. Both stimulation patterns provided equivalent significant UPDRS-III reduction and increased proactive inhibition relative to DBS OFF. Conclusions: This pilot study supports the safety and tolerability of burst DBS, with acute effects similar to conventional DBS. Further larger-scale studies are warranted given the potential benefits of burst DBS due to decreased total energy delivery.

AB - Background: Burst-patterned pallidal deep brain stimulation (DBS) in an animal model of Parkinson's disease (PD) yields significantly prolonged therapeutic benefit compared to conventional continuous DBS, but its value in patients remains unclear. Objectives: The aims were to evaluate the safety and tolerability of acute (<2 hours) burst DBS in PD patients and to evaluate preliminary clinical effectiveness relative to conventional DBS. Methods: Six PD patients were studied with DBS OFF, conventional DBS, and burst DBS. Unified Parkinson's Disease Rating Scale III (UPDRS-III) and proactive inhibition (using stop-signal task) were evaluated for each condition. Results: Burst and conventional DBS were equally tolerated without significant adverse events. Both stimulation patterns provided equivalent significant UPDRS-III reduction and increased proactive inhibition relative to DBS OFF. Conclusions: This pilot study supports the safety and tolerability of burst DBS, with acute effects similar to conventional DBS. Further larger-scale studies are warranted given the potential benefits of burst DBS due to decreased total energy delivery.

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Pilot Study of Acute Behavioral Effects of Pallidal Burst Stimulation in Parkinson's Disease

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