TY - JOUR
T1 - Pilot investigation into the sickness response to influenza vaccination in adults
T2 - Effect of depression and anxiety
AU - Harper, Jessica A.
AU - South, Charles
AU - Trivedi, Madhukar H.
AU - Toups, Marisa S.
N1 - Funding Information:
Data collection was supported by Academic Information Systems grant support, CTSA NIH Grant UL1-RR024982. This work was otherwise supported by the Center for Depression Research and Clinical Care, the O'Donnell Brain Institute, and the Department of Psychiatry at UTSW.
Publisher Copyright:
© 2017 Elsevier Inc.
PY - 2017/9
Y1 - 2017/9
N2 - Objective To determine whether depressed or anxious patients experience greater affective change than mentally healthy individuals following influenza vaccination. Methods Participants (n = 112) completed the Positive and Negative Affect Schedule (PANAS) before influenza vaccination and 1–2 days post-vaccination (M = 32.3 h). Pre- and post-vaccination PANAS scores were compared using two-tailed, paired-samples t-tests. Change in positive affect between participants with depression or anxiety and those without was compared using two-way ANOVA. Follow up positive affect was further examined using multiple linear regression. Results Positive affect decreased following vaccination (M = 2.18, 95% CI [1.07, 3.29], t(111) = 3.89, p < 0.001) for all participants and was more pronounced for those with anxiety or depression (F(1, 110) = 7.51, p = 0.009). Similarly, predicted follow up affect score was higher for those without a mental health conditions (β = 3.67, 95% CI [1.18, 6.16], t(103) = 2.92, p = 0.004). Conclusions These data suggest that influenza vaccine has a greater effect on affect in patients with depression and anxiety than in mentally healthy individuals. This effect was focused on positive affect, suggesting that influenza vaccine induced inflammation may be best suited to examine alterations in positive affect and positive valence systems.
AB - Objective To determine whether depressed or anxious patients experience greater affective change than mentally healthy individuals following influenza vaccination. Methods Participants (n = 112) completed the Positive and Negative Affect Schedule (PANAS) before influenza vaccination and 1–2 days post-vaccination (M = 32.3 h). Pre- and post-vaccination PANAS scores were compared using two-tailed, paired-samples t-tests. Change in positive affect between participants with depression or anxiety and those without was compared using two-way ANOVA. Follow up positive affect was further examined using multiple linear regression. Results Positive affect decreased following vaccination (M = 2.18, 95% CI [1.07, 3.29], t(111) = 3.89, p < 0.001) for all participants and was more pronounced for those with anxiety or depression (F(1, 110) = 7.51, p = 0.009). Similarly, predicted follow up affect score was higher for those without a mental health conditions (β = 3.67, 95% CI [1.18, 6.16], t(103) = 2.92, p = 0.004). Conclusions These data suggest that influenza vaccine has a greater effect on affect in patients with depression and anxiety than in mentally healthy individuals. This effect was focused on positive affect, suggesting that influenza vaccine induced inflammation may be best suited to examine alterations in positive affect and positive valence systems.
KW - Inflammation
KW - Influenza vaccine
KW - Major depressive disorder
KW - Positive affect
KW - Sickness behavior
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U2 - 10.1016/j.genhosppsych.2017.07.005
DO - 10.1016/j.genhosppsych.2017.07.005
M3 - Article
C2 - 28779589
AN - SCOPUS:85026497824
SN - 0163-8343
VL - 48
SP - 56
EP - 61
JO - General Hospital Psychiatry
JF - General Hospital Psychiatry
ER -