Physiological Actions of PTH and PTHrP IV: Vascular, Cardiovascular, and CNS Biology

Dwight A. Towler

doi:10.1016/B978-0-12-397166-1.00012-6

Physiological Actions of PTH and PTHrP IV: Vascular, Cardiovascular, and CNS Biology

Dwight A. Towler

Research output: Chapter in Book/Report/Conference proceeding › Chapter

1 Scopus citations

Abstract

This chapter gives an overview of PTH/PTHrP biology in the vasculature, emphasizing relationships with respect to cardiovascular biology and pathophysiology. Brief comment is given on central PTHrP and TIP39 actions that impact cardiovascular physiology-and exemplify the complexities of CNS regulation that have yet to be fully explored. Attention is then turned to chronic kidney disease-mineral and bone disorder (CKD-MBD) as a "perfect storm" of cardiometabolic risk arising in significant part from perturbed PTH1R signaling, and this discussion is used as a framework to highlight physiologically important interconnections within the emerging bone-vascular axis.

Original language	English (US)
Title of host publication	The Parathyroids
Subtitle of host publication	Basic and Clinical Concepts: Third Edition
Publisher	Elsevier Inc.
Pages	187-201
Number of pages	15
ISBN (Print)	9780123971661
DOIs	https://doi.org/10.1016/B978-0-12-397166-1.00012-6
State	Published - 2015

Keywords

Cardiomyocyte
Chronic kidney disease (CKD)
Coronary flow reserve (CFR)
Mineral and bone disorder (MBD)
PTH/PTHrP signaling
Pressor

ASJC Scopus subject areas

General Medicine

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10.1016/B978-0-12-397166-1.00012-6

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abstract = "This chapter gives an overview of PTH/PTHrP biology in the vasculature, emphasizing relationships with respect to cardiovascular biology and pathophysiology. Brief comment is given on central PTHrP and TIP39 actions that impact cardiovascular physiology-and exemplify the complexities of CNS regulation that have yet to be fully explored. Attention is then turned to chronic kidney disease-mineral and bone disorder (CKD-MBD) as a {"}perfect storm{"} of cardiometabolic risk arising in significant part from perturbed PTH1R signaling, and this discussion is used as a framework to highlight physiologically important interconnections within the emerging bone-vascular axis.",

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AB - This chapter gives an overview of PTH/PTHrP biology in the vasculature, emphasizing relationships with respect to cardiovascular biology and pathophysiology. Brief comment is given on central PTHrP and TIP39 actions that impact cardiovascular physiology-and exemplify the complexities of CNS regulation that have yet to be fully explored. Attention is then turned to chronic kidney disease-mineral and bone disorder (CKD-MBD) as a "perfect storm" of cardiometabolic risk arising in significant part from perturbed PTH1R signaling, and this discussion is used as a framework to highlight physiologically important interconnections within the emerging bone-vascular axis.

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KW - Chronic kidney disease (CKD)

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KW - Mineral and bone disorder (MBD)

KW - PTH/PTHrP signaling

KW - Pressor

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BT - The Parathyroids

PB - Elsevier Inc.

ER -

Physiological Actions of PTH and PTHrP IV: Vascular, Cardiovascular, and CNS Biology

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