Physiologic alterations in ataxia: Channeling changes into novel therapies

Vikram G. Shakkottai, Henry L. Paulson

Research output: Contribution to journalReview articlepeer-review

22 Scopus citations


The ataxias constitute a heterogeneous group of diseases in which cerebellar dysfunction typically underlies the major neurologic manifestations. It is increasingly clear that ataxia can result directly from mutations in ion channels or from perturbations in ion channel physiology in the absence of a primary channel defect. Neuronal dysfunction stemming from perturbed channel activity likely explains some motor deficits in episodic and degenerative ataxias. Understanding these pathophysiologic changes may reveal novel therapeutic targets for symptomatic treatment of ataxia.

Original languageEnglish (US)
Pages (from-to)1196-1201
Number of pages6
JournalArchives of neurology
Issue number10
StatePublished - 2009
Externally publishedYes

ASJC Scopus subject areas

  • Arts and Humanities (miscellaneous)
  • Clinical Neurology


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