Abstract
Background: Cryptochromes (CRYs) are transcriptional repressors that are critical components of the circadian clock. Results: We have identified a phosphorylation site in the CRY1 tail that is negatively regulated by the DNA repair enzyme DNA-dependent protein kinase. Conclusion: Phosphorylation of CRY1 on Ser-588 increases its half-life and lengthens the circadian period. Significance: The C-terminal tail of CRY1 modulates period length.
Original language | English (US) |
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Pages (from-to) | 35277-35286 |
Number of pages | 10 |
Journal | Journal of Biological Chemistry |
Volume | 288 |
Issue number | 49 |
DOIs | |
State | Published - Dec 6 2013 |
ASJC Scopus subject areas
- Biochemistry
- Molecular Biology
- Cell Biology