@article{da4408abc7cd4fd891a6304ffbd6240d,
title = "Phosphorylation of ETS1 by src family kinases prevents its recognition by the COP1 tumor suppressor",
abstract = "Oncoproteins and tumor suppressors antagonistically converge on critical nodes governing neoplastic growth, invasion, and metastasis. We discovered that phosphorylation of the ETS1 and ETS2 transcriptional oncoproteins at specific serine or threonine residues creates binding sites for the COP1 tumor suppressor protein, which is an ubiquitin ligase component, leading to their destruction. In the case of ETS1, however, phosphorylation of a neighboring tyrosine residue by Src family kinases disrupts COP1 binding, thereby stabilizing ETS1. Src-dependent accumulation of ETS1 in breast cancer cells promotes anchorage-independent growth invitro and tumor growth invivo. These findings expand the list of potential COP1 substrates to include proteins whose COP1-binding sites are subject to regulatory phosphorylation and provide insights into transformation by Src family kinases.",
author = "Gang Lu and Qing Zhang and Ying Huang and Jiaxi Song and Ross Tomaino and Tobias Ehrenberger and Elgene Lim and Wenbin Liu and Bronson, {Roderick T.} and Michaela Bowden and Jane Brock and Krop, {Ian E.} and Dillon, {Deborah A.} and Gygi, {Steven P.} and Mills, {Gordon B.} and Richardson, {Andrea L.} and Sabina Signoretti and Yaffe, {Michael B.} and Kaelin, {William G.}",
note = "Funding Information: The authors thank Drs. Todd Golub, William Hahn, Kimberly Briggs, and Sungwoo Lee for providing reagents, Drs. Brian D. Lehmann, Melinda E. Sanders, and Jennifer A. Pietenpol for advice and technical assistance on the immunohistochemical studies, and Dr. Wenyi Wei and members of Kaelin Laboratory for helpful discussions. G.L. is supported by the Ruth L. Kirschstein National Research Service Award postdoctoral fellowhip award. W.G.K. is a Howard Hughes Medical Institute (HHMI) investigator and is supported by grants from NIH, HHMI, and the Breast Cancer Research Foundation. ",
year = "2014",
month = aug,
day = "11",
doi = "10.1016/j.ccr.2014.06.026",
language = "English (US)",
volume = "26",
pages = "222--234",
journal = "Cancer Cell",
issn = "1535-6108",
publisher = "Cell Press",
number = "2",
}