Abstract
Comparisons of serine/threonine protein kinase (PK) and type IIβ phosphatidylinositol phosphate kinase (PIPK) structures with each other and also with other proteins reveal structural and functional similarity between the two kinases and proteins of the glutathione synthase fold (ATP-grasp). This suggests that these enzymes are evolutionarily related. The structure of PIPK, which clearly resembles both PK and ATP-grasp, provides a link between the two proteins and establishes that the C-terminal domains of PK, PIPK and ATP-grasp share the same fold. The functional implications of the proposed homology are discussed.
Original language | English (US) |
---|---|
Pages (from-to) | 239-247 |
Number of pages | 9 |
Journal | Journal of Molecular Biology |
Volume | 291 |
Issue number | 2 |
DOIs | |
State | Published - Aug 13 1999 |
Keywords
- ATP-grasp fold
- Fold evolution
- Lipid kinase
- Protein kinase
- SAICAR synthase
ASJC Scopus subject areas
- Structural Biology
- Molecular Biology