Phosphatidic acid is a pH biosensor that links membrane biogenesis to metabolism

Barry P. Young, John J.H. Shin, Rick Orij, Jesse T. Chao, Shu Chen Li, Xue Li Guan, Anthony Khong, Eric Jan, Markus R. Wenk, William A. Prinz, Gertien J. Smits, Christopher J.R. Loewen

Research output: Contribution to journalArticlepeer-review

183 Scopus citations


Recognition of lipids by proteins is important for their targeting and activation in many signaling pathways, but the mechanisms that regulate such interactions are largely unknown. Here, we found that binding of proteins to the ubiquitous signaling lipid phosphatidic acid (PA) depended on intracellular pH and the protonation state of its phosphate headgroup. In yeast, a rapid decrease in intracellular pH in response to glucose starvation regulated binding of PA to a transcription factor, Opi1, that coordinately repressed phospholipid metabolic genes. This enabled coupling of membrane biogenesis to nutrient availability.

Original languageEnglish (US)
Pages (from-to)1085-1088
Number of pages4
Issue number5995
StatePublished - Aug 27 2010
Externally publishedYes

ASJC Scopus subject areas

  • General


Dive into the research topics of 'Phosphatidic acid is a pH biosensor that links membrane biogenesis to metabolism'. Together they form a unique fingerprint.

Cite this