Phenotypic characterization of autoreactive T cells in multiple sclerosis

Robert B. Ratts; Nitin J. Karandikar; Rehana Z. Hussain; Judy Choy; Sara C. Northrop; Amy E. Lovett-Racke; Michael K. Racke

doi:10.1016/j.jneuroim.2006.06.010

Phenotypic characterization of autoreactive T cells in multiple sclerosis

Robert B. Ratts, Nitin J. Karandikar, Rehana Z. Hussain, Judy Choy, Sara C. Northrop, Amy E. Lovett-Racke, Michael K. Racke

Research output: Contribution to journal › Article › peer-review

22 Scopus citations

Abstract

MS has been hypothesized to result from autoreactive T cell responses against myelin antigens. In this report, we examined myelin-specific CD8 and CD4 T cells for two markers differentially expressed on naïve, memory and chronically stimulated T cells, CD28 and CD57. We observed differential expression on CD8 T cells in response to myelin antigens, but not in response to the recall antigen mumps. We demonstrate these cells display reduced proliferation and this may explain why therapies that limit the proliferation of T cells have had little effect on the course of MS, particularly later in the course of the disease.

Original language	English (US)
Pages (from-to)	100-110
Number of pages	11
Journal	Journal of Neuroimmunology
Volume	178
Issue number	1-2
DOIs	https://doi.org/10.1016/j.jneuroim.2006.06.010
State	Published - Sep 2006

Keywords

Autoimmunity
CD81
T cells

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Neurology
Clinical Neurology

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10.1016/j.jneuroim.2006.06.010

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@article{2f007053c96d4c86bda5c681349805cd,

title = "Phenotypic characterization of autoreactive T cells in multiple sclerosis",

abstract = "MS has been hypothesized to result from autoreactive T cell responses against myelin antigens. In this report, we examined myelin-specific CD8 and CD4 T cells for two markers differentially expressed on na{\"i}ve, memory and chronically stimulated T cells, CD28 and CD57. We observed differential expression on CD8 T cells in response to myelin antigens, but not in response to the recall antigen mumps. We demonstrate these cells display reduced proliferation and this may explain why therapies that limit the proliferation of T cells have had little effect on the course of MS, particularly later in the course of the disease.",

keywords = "Autoimmunity, CD81, T cells",

author = "Ratts, {Robert B.} and Karandikar, {Nitin J.} and Hussain, {Rehana Z.} and Judy Choy and Northrop, {Sara C.} and Lovett-Racke, {Amy E.} and Racke, {Michael K.}",

note = "Funding Information: This work was supported by grants from the NIH NS-37513, NS-44250, AI-47133, National Multiple Sclerosis Society (NMSS) grant RG2969-B-7, a grant from the Yellow Rose Foundation (Dallas, Texas, USA) (M.K.R.) and NIH grant AI53439 (N.J.K.). N.J.K. and A.E.L.R. are Harry Weaver Neuroscience Scholars of the National Multiple Sclerosis Society.",

year = "2006",

month = sep,

doi = "10.1016/j.jneuroim.2006.06.010",

language = "English (US)",

volume = "178",

pages = "100--110",

journal = "Journal of Neuroimmunology",

issn = "0165-5728",

publisher = "Elsevier",

number = "1-2",

}

TY - JOUR

T1 - Phenotypic characterization of autoreactive T cells in multiple sclerosis

AU - Ratts, Robert B.

AU - Karandikar, Nitin J.

AU - Hussain, Rehana Z.

AU - Choy, Judy

AU - Northrop, Sara C.

AU - Lovett-Racke, Amy E.

AU - Racke, Michael K.

N1 - Funding Information: This work was supported by grants from the NIH NS-37513, NS-44250, AI-47133, National Multiple Sclerosis Society (NMSS) grant RG2969-B-7, a grant from the Yellow Rose Foundation (Dallas, Texas, USA) (M.K.R.) and NIH grant AI53439 (N.J.K.). N.J.K. and A.E.L.R. are Harry Weaver Neuroscience Scholars of the National Multiple Sclerosis Society.

PY - 2006/9

Y1 - 2006/9

N2 - MS has been hypothesized to result from autoreactive T cell responses against myelin antigens. In this report, we examined myelin-specific CD8 and CD4 T cells for two markers differentially expressed on naïve, memory and chronically stimulated T cells, CD28 and CD57. We observed differential expression on CD8 T cells in response to myelin antigens, but not in response to the recall antigen mumps. We demonstrate these cells display reduced proliferation and this may explain why therapies that limit the proliferation of T cells have had little effect on the course of MS, particularly later in the course of the disease.

AB - MS has been hypothesized to result from autoreactive T cell responses against myelin antigens. In this report, we examined myelin-specific CD8 and CD4 T cells for two markers differentially expressed on naïve, memory and chronically stimulated T cells, CD28 and CD57. We observed differential expression on CD8 T cells in response to myelin antigens, but not in response to the recall antigen mumps. We demonstrate these cells display reduced proliferation and this may explain why therapies that limit the proliferation of T cells have had little effect on the course of MS, particularly later in the course of the disease.

KW - Autoimmunity

KW - CD81

KW - T cells

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AN - SCOPUS:33748121187

SN - 0165-5728

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EP - 110

JO - Journal of Neuroimmunology

JF - Journal of Neuroimmunology

IS - 1-2

ER -

Phenotypic characterization of autoreactive T cells in multiple sclerosis

Abstract

Keywords

ASJC Scopus subject areas

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