Phase I trial of a novel diphtheria toxin/granulocyte macrophage colony-stimulating factor fusion protein (DT₃₈₈GMCSF) for refractory or relapsed acute myeloid leukemia

Medicine & Life Sciences

• Diphtheria Toxin 100%
• Granulocyte-Macrophage Colony-Stimulating Factor 75%
• Acute Myeloid Leukemia 68%
• Proteins 26%
• Maximum Tolerated Dose 12%
• Interleukin-18 12%
• Bone Marrow 11%
• Aspartate Aminotransferases 10%
• Liver 7%
• Serum 7%
• Macrophage Inflammatory Proteins 6%
• Diphtheria 6%
• Macrophage Colony-Stimulating Factor 6%
• Hepatic Encephalopathy 6%
• Drug Therapy 6%
• Liver Failure 5%
• Interleukin-12 5%
• Interleukin-1 5%
• Wounds and Injuries 4%
• Interleukin-8 4%
• Catalytic Domain 4%
• In Vitro Techniques 4%
• Hepatocytes 4%
• Research Design 4%
• Interleukin-6 3%
• Tumor Necrosis Factor-alpha 3%
• Macrophages 3%
• Cytokines 3%
• Cell Line 3%
• Safety 2%
• Enzymes 2%
• Therapeutics 0%