Pharmacokinetics of clozapine and risperidone: A review of recent literature

Matthew J. Byerly, C. Lindsay DeVane

Research output: Contribution to journalReview articlepeer-review

123 Scopus citations


The current literature describing the pharmacokinetics of the atypical antipsychotics clozapine and risperidone is reviewed, and discussion on the clinical significance of these data is presented. These drugs are well absorbed when taken orally but are poorly bioavailable because of presystemic elimination. They are highly cleared by hepatic metabolism involving specific P460 isozymes. Risperidone elimination produces a potent active metabolite. Neither of the drugs has received extensive study related to drug-drug interactions, but several are potentially important because a purported therapeutic plasma concentration range is proposed for clozapine and a possible curvilinear dose response relationship has been reported for risperidone. The current clinical pharmacokinetic database for these atypical antipsychotics suggests that much can be learned with additional study that would be of value in individualizing their dosage regimens.

Original languageEnglish (US)
Pages (from-to)177-187
Number of pages11
JournalJournal of clinical psychopharmacology
Issue number2
StatePublished - Apr 26 1996

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Pharmacology (medical)


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