TY - JOUR
T1 - Pharmacogenetics of minimal residual disease response in children with B-precursor acute lymphoblastic leukemia
T2 - A report from the children's oncology group
AU - Davies, Stella M.
AU - Borowitz, Michael J.
AU - Rosner, Gary L.
AU - Ritz, Kristin
AU - Devidas, Meenakshi
AU - Winick, Naomi
AU - Martin, Paul L.
AU - Bowman, Paul
AU - Elliott, James
AU - Willman, Cheryl
AU - Das, Soma
AU - Cook, Edwin H.
AU - Relling, Mary V.
PY - 2008/3/15
Y1 - 2008/3/15
N2 - Minimal residual disease (MRD) as a marker of antileukemic drug efficacy is being used to assess risk status and, in some cases, to adjust the intensity of therapy. Within known prognostic categories, the determinants of MRD are not known. We measured MRD by flow cytometry at day 8 (in blood) and at day 28 (in bone marrow) of induction therapy in more than 1000 children enrolled in Pediatric Oncology Group therapy protocols 9904, 9905, and 9906. We classified patients as "best risk" if they had cleared MRD by day 8 of therapy and as "worst risk" if they had MRD remaining in bone marrow at day 28, and tested whether MRD was related to polymorphisms in 16 loci in genes hypothesized to influence response to therapy in acute lymphoblastic leukemia (ALL). After adjusting for known prognostic features such as presence of the TEL-AML1 rearrangement, National Cancer Institute (NCI) risk status, ploidy, and race, the G allele of a common polymorphism in chemokine receptor 5 (CCR5) was associated with more favorable MRD status than the A allele (P = .009, logistic regression), when comparing "best" and "worst" risk groups. These data are consistent with growing evidence that both acquired and host genetics influence response to cancer therapy.
AB - Minimal residual disease (MRD) as a marker of antileukemic drug efficacy is being used to assess risk status and, in some cases, to adjust the intensity of therapy. Within known prognostic categories, the determinants of MRD are not known. We measured MRD by flow cytometry at day 8 (in blood) and at day 28 (in bone marrow) of induction therapy in more than 1000 children enrolled in Pediatric Oncology Group therapy protocols 9904, 9905, and 9906. We classified patients as "best risk" if they had cleared MRD by day 8 of therapy and as "worst risk" if they had MRD remaining in bone marrow at day 28, and tested whether MRD was related to polymorphisms in 16 loci in genes hypothesized to influence response to therapy in acute lymphoblastic leukemia (ALL). After adjusting for known prognostic features such as presence of the TEL-AML1 rearrangement, National Cancer Institute (NCI) risk status, ploidy, and race, the G allele of a common polymorphism in chemokine receptor 5 (CCR5) was associated with more favorable MRD status than the A allele (P = .009, logistic regression), when comparing "best" and "worst" risk groups. These data are consistent with growing evidence that both acquired and host genetics influence response to cancer therapy.
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U2 - 10.1182/blood-2007-09-114082
DO - 10.1182/blood-2007-09-114082
M3 - Article
C2 - 18182569
AN - SCOPUS:42449157637
SN - 0006-4971
VL - 111
SP - 2984
EP - 2990
JO - Blood
JF - Blood
IS - 6
ER -