PET/CT of dementia

Katherine Zukotynski; Phillip H. Kuo; David Mikulis; Pedro Rosa-Neto; Antonio P. Strafella; Rathan M. Subramaniam; Sandra E. Black

doi:10.2214/AJR.18.19822

PET/CT of dementia

Katherine Zukotynski, Phillip H. Kuo, David Mikulis, Pedro Rosa-Neto, Antonio P. Strafella, Rathan M. Subramaniam, Sandra E. Black

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

OBJECTIVE. In this article, we review the literature on PET/CT in the management of dementia, present evidence for best clinical practices, and discuss recent advances in the field. CONCLUSION. Standard-of-care imaging for dementia includes CT and MRI, primarily for excluding vascular lesions or masses, detecting atrophy, and monitoring disease severity. PET/CT is a powerful functional modality that can differentiate dementia types and influence management. Fluorine-18-FDG PET/CT reveals the spatial pattern of glucose metabolism in the brain. More recently, radiotracers for PET have been developed that bind to amyloid protein, tau protein, and neuroinflammatory markers.

Original language	English (US)
Pages (from-to)	246-259
Number of pages	14
Journal	American Journal of Roentgenology
Volume	211
Issue number	2
DOIs	https://doi.org/10.2214/AJR.18.19822
State	Published - Aug 2018

Keywords

Amyloid
Dementia
Imaging
PET/CT
Tau

ASJC Scopus subject areas

Radiology Nuclear Medicine and imaging

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10.2214/AJR.18.19822

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title = "PET/CT of dementia",

abstract = "OBJECTIVE. In this article, we review the literature on PET/CT in the management of dementia, present evidence for best clinical practices, and discuss recent advances in the field. CONCLUSION. Standard-of-care imaging for dementia includes CT and MRI, primarily for excluding vascular lesions or masses, detecting atrophy, and monitoring disease severity. PET/CT is a powerful functional modality that can differentiate dementia types and influence management. Fluorine-18-FDG PET/CT reveals the spatial pattern of glucose metabolism in the brain. More recently, radiotracers for PET have been developed that bind to amyloid protein, tau protein, and neuroinflammatory markers.",

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AU - Zukotynski, Katherine

AU - Kuo, Phillip H.

AU - Mikulis, David

AU - Rosa-Neto, Pedro

AU - Strafella, Antonio P.

AU - Subramaniam, Rathan M.

AU - Black, Sandra E.

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AB - OBJECTIVE. In this article, we review the literature on PET/CT in the management of dementia, present evidence for best clinical practices, and discuss recent advances in the field. CONCLUSION. Standard-of-care imaging for dementia includes CT and MRI, primarily for excluding vascular lesions or masses, detecting atrophy, and monitoring disease severity. PET/CT is a powerful functional modality that can differentiate dementia types and influence management. Fluorine-18-FDG PET/CT reveals the spatial pattern of glucose metabolism in the brain. More recently, radiotracers for PET have been developed that bind to amyloid protein, tau protein, and neuroinflammatory markers.

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KW - Dementia

KW - Imaging

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KW - Tau

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PET/CT of dementia

Abstract

Keywords

ASJC Scopus subject areas

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