TY - JOUR
T1 - Peripheral Neuropathy and Nerve Compression Syndromes in Burns
AU - Strong, Amy L.
AU - Agarwal, Shailesh
AU - Cederna, Paul S.
AU - Levi, Benjamin
N1 - Funding Information:
Disclosures: Dr B. Levi was funded by 1K08GM109105-01, Plastic Surgery Foundation, American Association of Plastic Surgery Award, American Association for the Surgery of Trauma, American College of Surgeons Clowes Award and the Association of Academic Surgery. Dr B. Levi collaborates on a project unrelated to this review with Boehringer Ingelheim and has a Patent application on Rapamycin for use in heterotopic ossification which has not been licensed. The other authors have nothing to disclose.
Publisher Copyright:
© 2017 Elsevier Inc.
PY - 2017/10
Y1 - 2017/10
N2 - Peripheral neuropathy and nerve compression syndromes lead to substantial morbidity following burn injury. Patients present with pain, paresthesias, or weakness along a specific nerve distribution or experience generalized peripheral neuropathy. The symptoms manifest at various times from within one week of hospitalization to many months after wound closure. Peripheral neuropathy may be caused by vascular occlusion of vasa nervorum, inflammation, neurotoxin production leading to apoptosis, and direct destruction of nerves from the burn injury. This article discusses the natural history, diagnosis, current treatments, and future directions for potential interventions for peripheral neuropathy and nerve compression syndromes related to burn injury.
AB - Peripheral neuropathy and nerve compression syndromes lead to substantial morbidity following burn injury. Patients present with pain, paresthesias, or weakness along a specific nerve distribution or experience generalized peripheral neuropathy. The symptoms manifest at various times from within one week of hospitalization to many months after wound closure. Peripheral neuropathy may be caused by vascular occlusion of vasa nervorum, inflammation, neurotoxin production leading to apoptosis, and direct destruction of nerves from the burn injury. This article discusses the natural history, diagnosis, current treatments, and future directions for potential interventions for peripheral neuropathy and nerve compression syndromes related to burn injury.
KW - Nerve compression syndromes
KW - Peripheral nerves
KW - Peripheral neuropathy
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U2 - 10.1016/j.cps.2017.05.010
DO - 10.1016/j.cps.2017.05.010
M3 - Review article
C2 - 28888304
AN - SCOPUS:85025138275
SN - 0094-1298
VL - 44
SP - 793
EP - 803
JO - Clinics in Plastic Surgery
JF - Clinics in Plastic Surgery
IS - 4
ER -