Peripheral corneal disorders

Jeffrey B. Robin, David J. Schanzlin, Steven Verity, Bruce A. Barron, Robert C. Arffa, Enrique Suarez, Herbert E. Kaufman

Research output: Contribution to journalReview articlepeer-review

75 Scopus citations


The peripheral cornea is anatomically and physiologically distinct from its central counterpart. The major differences relate to the gradual transition of corneal tissues to those of the conjunctiva, episclera, and sclera; furthermore, the vascular structures, lymphatics, and inflammatory cells from these neighboring structures are intimately associated with the limbus and periphery of the cornea. The peripheral cornea is thereby predisposed to three main classes of disorders which do not normally involve the central cornea. First, local conditions affecting the sclera and conjunctiva may secondarily spread to involve the limbus and peripheral cornea. These include several infectious diseases, as well as hypersensitivity conditions, mass lesions, and degenerations. Second, due to the associated blood vessels and lymphatics, the peripheral cornea may be involved in a variety of systemic diseases, including vasculitides, autoimmune disorders, and abnormal metabolic conditions. Finally, there are several conditions, such as the noninflammatory peripheral degenerations, which primarily affect the peripheral cornea without associated ocular or systemic changes. In this review, we present a classification and discussion of the various disorders which may involve the peripheral cornea.

Original languageEnglish (US)
Pages (from-to)1-36
Number of pages36
JournalSurvey of Ophthalmology
Issue number1
StatePublished - 1986


  • Mooren's ulcer
  • Terrien's marginal degeneration
  • collagen vascular diseases
  • corneal degenerations
  • corneal tumors
  • dellen
  • infectious keratitis
  • marginal ulcer
  • pellucid marginal degeneration
  • peripheral cornea
  • phlyctenulosis
  • rosacea
  • vernal keratoconjunctivitis

ASJC Scopus subject areas

  • Ophthalmology


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