TY - JOUR
T1 - Peripheral biological correlates of suicidality in children and adolescents
T2 - A systematic review and meta-analysis
AU - Pak, Thomas K.
AU - Ayvaci, Emine Rabia
AU - Carmody, Thomas
AU - Jamma, Limi
AU - Feng, Zihang
AU - Nekovei, Arya
AU - Emslie, Graham J
AU - Trivedi, Madhukar H
N1 - Publisher Copyright:
© 2025 The Author(s)
PY - 2025/4/18
Y1 - 2025/4/18
N2 - A systematic review and meta-analysis were conducted to identify peripheral biological correlates of suicidality in children and adolescents. The review was pre-registered through PROSPERO (CRD42023417128) and included four databases (PubMed, Cochrane Library, Embase, and PsycINFO). From 27,977 non-duplicated articles, 102 full-text studies were selected. Studies investigated suicide attempts (n = 52), suicidal ideation (n = 42), or individuals with suicidal ideation or attempts grouped together (n = 22). Seropositive toxoplasmosis, cortisol, neutrophil, and neutrophil to lymphocyte ratio (NLR) exhibited significant effect size after Bonferroni correction. Effect sizes for biological correlates of suicidality were pooled using Cohen's d (effect size = −0.04, 95% confidence interval [CI]: −1.36 to 1.27) and odds ratio (effect size = −0.31, 95% CI: −1.06 to 0.42). Meta-regression analysis revealed that type of suicidality, type of control, means collected, and sample size significantly impacted the pooled effect size. Analysis showed significant publication bias and heterogeneity, as well as notable moderators and potential biomarkers for future research.
AB - A systematic review and meta-analysis were conducted to identify peripheral biological correlates of suicidality in children and adolescents. The review was pre-registered through PROSPERO (CRD42023417128) and included four databases (PubMed, Cochrane Library, Embase, and PsycINFO). From 27,977 non-duplicated articles, 102 full-text studies were selected. Studies investigated suicide attempts (n = 52), suicidal ideation (n = 42), or individuals with suicidal ideation or attempts grouped together (n = 22). Seropositive toxoplasmosis, cortisol, neutrophil, and neutrophil to lymphocyte ratio (NLR) exhibited significant effect size after Bonferroni correction. Effect sizes for biological correlates of suicidality were pooled using Cohen's d (effect size = −0.04, 95% confidence interval [CI]: −1.36 to 1.27) and odds ratio (effect size = −0.31, 95% CI: −1.06 to 0.42). Meta-regression analysis revealed that type of suicidality, type of control, means collected, and sample size significantly impacted the pooled effect size. Analysis showed significant publication bias and heterogeneity, as well as notable moderators and potential biomarkers for future research.
KW - Psychology
KW - Public health
UR - http://www.scopus.com/inward/record.url?scp=105002039776&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=105002039776&partnerID=8YFLogxK
U2 - 10.1016/j.isci.2025.112290
DO - 10.1016/j.isci.2025.112290
M3 - Article
C2 - 40264798
AN - SCOPUS:105002039776
SN - 2589-0042
VL - 28
JO - iScience
JF - iScience
IS - 4
M1 - 112290
ER -