Perineurial cell hyperplasia in early-onset polyneuropathy with multiple cranial neuropathies

Gil I. Wolfe, Richard D. Brower, Dennis K. Burns

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


We describe a patient who as a teenager developed a sensory-motor polyneuropathy with optic atrophy. Over the next three decades, multiple cranial neuropathies appeared. Striking areas of subperineurial cellular proliferation were observed on sural nerve biopsy. The ultrastructural and immunohistochemical characteristics of these aggregates were those of perineurial cell hyperplasia. To our knowledge, this is the second full report associating perineurial cell hyperplasia with a sensory-motor polyneuropathy and the first in the English literature. Copyright (C) 2000 Elsevier Science B.V.

Original languageEnglish (US)
Pages (from-to)503-506
Number of pages4
JournalNeuromuscular Disorders
Issue number7
StatePublished - Oct 2000


  • Cranial neuropathy
  • Hyperplasia
  • Optic atrophy
  • Perineurial cells
  • Polyneuropathy

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Neurology
  • Clinical Neurology
  • Genetics(clinical)


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