Abstract
Contrast agents that can diffuse freely into or within tissue have numerous attractive features for perfusion imaging. Here we present preliminary data illustrating the suitability of hyperpolarized 13C labeled 2-methylpropan-2-ol (also known as dimethylethanol, tertiary butyl alcohol and tert-butanol) as a freely diffusible contrast agent for magnetic resonance perfusion imaging. Dynamic 13C images acquired in rat brain with a balanced steady-state free precession sequence following administration of hyperpolarized 2-methylpropan-2-ol show that this agent can be imaged with 2-4s temporal resolution, 2 mm slice thickness, and 700 μm in-plane resolution while retaining adequate signal-to-noise ratio. 13C relaxation measurements on 2-methylpropan-2-ol in blood at 9.4T yield T1 = 46 ± 4s and T2 = 0.55 ± 0.03s. In the rat brain at 4.7T, analysis of the temporal dynamics of the balanced steady-state free precession image intensity in tissue and venous blood indicate that 2-methylpropan-2-ol has a T2 of roughly 2-4s and a T1 of 43 ± 24s. In addition, the images indicate that 2-methylpropan-2-ol is freely diffusible in brain and hence has a long residence time in tissue; this in turn makes it possible to image the agent continuously for tens of seconds. These characteristics show that 2-methylpropan-2-ol is a promising agent for robust and quantitative perfusion imaging in the brain and body.
Original language | English (US) |
---|---|
Pages (from-to) | 746-755 |
Number of pages | 10 |
Journal | Magnetic resonance in medicine |
Volume | 66 |
Issue number | 3 |
DOIs | |
State | Published - Sep 2011 |
Keywords
- blood flow imaging
- carbon-13
- contrast agents
- functional imaging
- hyperpolarization
- perfusion imaging
ASJC Scopus subject areas
- Radiology Nuclear Medicine and imaging