TY - JOUR
T1 - Peptide nucleic acids
T2 - Expanding the scope of nucleic acid recognition
AU - Corey, David R.
N1 - Funding Information:
I thank Mieczyslaw Piatyszek (Geron Corporation, Menlo Park, CA, USA), Donald Doyle and Susan Hamilton for thoughtful comments on this manuscript and Steven Sherwood and Geron Corporation for supplying Fig. 4. This work was supported by a grant from the Robert A. Welch Foundation (I-1244) and an award f?om the CaP CURE association. The author is an Assistant Investigator with the Howard Hughes Medical Institute.
PY - 1997/6
Y1 - 1997/6
N2 - Peptide nucleic acids (PNAs) are DNA analogs containing neutral amide backbone linkages. PNAs are stable to degradation by enzymes and hybridize to complementary sequences with higher affinity than analogous DNA oligomers. PNA synthesis employs protocols derived from solid-phase peptide synthesis, making the methodology straightforward and flexible. PNAs are being incorporated into an expanding set of applications, including genome mapping, the identification of mutations and measurement of telomere length. The growth in the popularity of PNAs as a tool for nucleic acid recognition should accelerate as the properties of PNAs become more familiar.
AB - Peptide nucleic acids (PNAs) are DNA analogs containing neutral amide backbone linkages. PNAs are stable to degradation by enzymes and hybridize to complementary sequences with higher affinity than analogous DNA oligomers. PNA synthesis employs protocols derived from solid-phase peptide synthesis, making the methodology straightforward and flexible. PNAs are being incorporated into an expanding set of applications, including genome mapping, the identification of mutations and measurement of telomere length. The growth in the popularity of PNAs as a tool for nucleic acid recognition should accelerate as the properties of PNAs become more familiar.
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U2 - 10.1016/S0167-7799(97)01037-8
DO - 10.1016/S0167-7799(97)01037-8
M3 - Article
C2 - 9183865
AN - SCOPUS:0030917307
SN - 0167-7799
VL - 15
SP - 224
EP - 229
JO - Trends in Biotechnology
JF - Trends in Biotechnology
IS - 6
ER -