@article{ebd0d5c55a294249b8d80fb2fd835327,
title = "PedsQL{\texttrademark} Gastrointestinal Symptoms Scales and Gastrointestinal Worry Scales in pediatric patients with functional and organic gastrointestinal diseases in comparison to healthy controls",
abstract = "Objective: The primary objective was to compare the gastrointestinal (GI) symptoms and worry of pediatric patients with functional GI disorders (FGIDs) and organic GI diseases to healthy controls utilizing the Pediatric Quality of Life Inventory{\texttrademark} (PedsQL{\texttrademark}) Gastrointestinal Symptoms and Worry Scales for patient self-reports ages 5–18 years and parent proxy-reports for ages 2–18 years. The secondary objective was to compare FGIDs and organic GI diseases to each other. Methods: The PedsQL{\texttrademark} Gastrointestinal Symptoms and Worry Scales were completed in a 9-site study by 587 pediatric patients with GI disorders and 685 parents of patients. Patients had physician-diagnosed GI disorders (chronic constipation, functional abdominal pain, irritable bowel syndrome, functional dyspepsia, Crohn{\textquoteright}s disease, ulcerative colitis, and gastroesophageal reflux disease). Ten Gastrointestinal Symptoms Scales measuring Stomach Pain, Stomach Discomfort When Eating, Food and Drink Limits, Trouble Swallowing, Heartburn and Reflux, Nausea and Vomiting, Gas and Bloating, Constipation, Blood, and Diarrhea were administered along with two Gastrointestinal Worry Scales. Five hundred and thirteen healthy children and 337 parents of healthy children completed the PedsQL{\texttrademark} Gastrointestinal Scales in an Internet panel survey. Results: The PedsQL{\texttrademark} Gastrointestinal Symptoms and Worry Scales distinguished between pediatric patients with FGIDs and organic GI diseases in comparison with healthy controls, supporting known-groups validity. Patients with FGIDs reported more GI symptoms and worry than patients with organic GI diseases. Conclusions: The PedsQL{\texttrademark} Gastrointestinal Symptoms and Worry Scales may be utilized as common metrics across pediatric patient groups with FGIDs and organic GI diseases and healthy samples to measure GI-specific symptoms in clinical research and practice.",
keywords = "Gastroenterology, Gastrointestinal, Health-related quality of life, Patient-reported outcomes, Pediatrics, PedsQL, Symptoms",
author = "Varni, {James W.} and Bendo, {Cristiane B.} and Jolanda Denham and Shulman, {Robert J.} and Self, {Mariella M.} and Neigut, {Deborah A.} and Samuel Nurko and Patel, {Ashish S.} and Franciosi, {James P.} and Miguel Saps and Alyson Yeckes and Annette Langseder and Shehzad Saeed and Pohl, {John F.}",
note = "Funding Information: No funding was specifically designated for the PedsQL{\texttrademark} Gastrointestinal Symptoms Module field test study data collection effort or manuscript preparation. Item development for the PedsQL{\texttrademark} Gastrointestinal Symptoms Module was previously supported by Takeda Pharmaceuticals North America, Inc. Data collection for the healthy controls sample was supported by intramural funding from the Texas A&M University Foundation. Funding Information: Dr. Varni holds the copyright and the trademark for the PedsQL{\texttrademark} and receives financial compensation from the Mapi Research Trust, which is a nonprofit research institute that charges distribution fees to for-profit companies that use the Pediatric Quality of Life Inventory{\texttrademark}. Dr. Varni received investigator-initiated funding from Takeda Pharmaceuticals North America, Inc. (Deerfield, Illinois) for the previous item generation qualitative methods study. Dr. Pohl received investigator-initiated funding from Takeda Pharmaceuticals North America, Inc. (Deerfield, Illinois) for the previous item generation qualitative methods study. Drs. Varni and Pohl did not receive funding from Takeda Pharmaceuticals North America, Inc., for the current quantitative methods field test study. Dr. Pohl has received the following funding: INSPPIRE to Study Acute Recurrent and Chronic Pancreatitis is Children, Grant # 10987759, National Institutes of Health (NIH), National Institute of Diabetes and Digestive and Kidney Diseases. Dr. Nurko is supported by NIH Grant K24DK082792A. Dr. Shulman is supported by NIH Grants R01 NR013497, R34 AT006986, and T32 DK007664. These grants are not related to the current study. The other authors report no competing interests related to this study. Publisher Copyright: {\textcopyright} 2014, Springer International Publishing Switzerland.",
year = "2015",
month = feb,
doi = "10.1007/s11136-014-0781-x",
language = "English (US)",
volume = "24",
pages = "363--378",
journal = "Quality of Life Research",
issn = "0962-9343",
publisher = "Springer Netherlands",
number = "2",
}