@article{a6688b405a6f4f1a8fec27451ef7e77c,
title = "Pediatric paraneoplastic neuromyelitis optica spectrum disorder associated with ovarian teratoma",
abstract = "Neuromyelitis optica spectrum disorder is an inflammatory condition of the central nervous system typically manifesting as myelitis, optic neuritis, and/or area postrema syndrome. Here, we present a pediatric patient who developed symptoms consistent with area postrema syndrome with positive anti-aquaporin-4 (AQP4) antibodies who was also found to have an ovarian teratoma. Pathological specimens revealed the presence of aquaporin-4. This was felt to be the antigenic trigger that led to the patient{\textquoteright}s condition. She suffered no further clinical attacks and seroconverted to negative AQP4 status upon teratoma removal. This case varies from others, in that the paraneoplastic presentation occurred in a pediatric patient and in that the patient has not required maintenance immunotherapy after teratoma removal.",
keywords = "AQP4, Pediatric NMOSD, paraneoplastic",
author = "Lauren Tardo and Cynthia Wang and Veena Rajaram and Greenberg, {Benjamin M.}",
note = "Funding Information: The author(s) declared the following potential conflicts of interest with respect to the research, authorship, and/or publication of this article: L.T. serves as an unpaid member on the medical advisory board of the MOG project. C.W. and V.R. have nothing to declare. B.M.G. has received consulting fees from Alexion, Novartis, EMD Serono, Viela Bio, Genentech/Roche, Greenwhich Biosciences, Axon Advisors, Rubin Anders, ABCAM, and PRIME Education. He has received grant funding from Patient-Centered Outcomes Research Institute (PCORI), National Institutes of Health (NIH), National Multiple Sclerosis Society (NMSS), the Siegel Rare Neuroimmune Association, Clene Nanomedicine, and the Guthy-Jackson Charitable Foundation for Neuromyelitis Optica (NMO). He serves as an unpaid member of the board of the Siegel Rare Neuroimmune Association Publisher Copyright: {\textcopyright} The Author(s), 2021.",
year = "2022",
month = jan,
doi = "10.1177/13524585211037582",
language = "English (US)",
volume = "28",
pages = "160--163",
journal = "Multiple Sclerosis Journal",
issn = "1352-4585",
publisher = "SAGE Publications Ltd",
number = "1",
}