Pediatric brainstem gliomas: A retrospective study of 180 patients from the seer database

Syed I. Khalid, Ryan Kelly, Owoicho Adogwa, Adam Carlton, Edric Tam, Salik Naqvi, Jacob Kushkuley, Shahjehan Ahmad, Josha Woodward, Ryan Khanna, Mark Davison, Lorenzo Munoz, Richard Byrne

Research output: Contribution to journalArticlepeer-review

11 Scopus citations


Background/Aims: Large population-based studies are needed to assess the epidemiology and survival risk factors associated with pediatric brainstem gliomas. This retrospective study explores factors that may influence survival in this population. Methods: Utilizing the SEER database, the authors retrospectively assessed survival in histologically confirmed brainstem gliomas in patients aged 17 and younger. Survival was described with Kaplan-Meyer curves and multivariate regression analysis. Results: This analysis of 180 cases showed that age (hazard ratio [HR] 1.04, 95% CI 0.96-1.14, p = 0.34), non-white race (HR 1.00, 95% CI 0.35-2.85 p > 0.99), distant or invasive extension of the tumor (HR 0.4, 95% CI 0.08-2.53, p = 0.37), and radiation therapy (HR 1.27, 95% CI 0.52-3.11, p = 0.61) were not associated with decreased survival. High-grade tumor status (HR 8.64, 95% CI 3.49-21.41, p < 0.001) was associated with decreased survival. Partial resection (HR 0.11, 95% CI 0.04-0.30, p < 0.001) and gross-Total resection (HR 0.03, 95% CI 0.01-0.14, p < 0.001) were associated with improved survival. Conclusions: High-grade brainstem gliomas have a worse prognosis. Early diagnosis and surgery appear to be associated with improved survival, while the role of radiation is unclear.

Original languageEnglish (US)
Pages (from-to)151-164
Number of pages14
JournalPediatric Neurosurgery
Issue number3
StatePublished - Jul 1 2019
Externally publishedYes


  • Brainstem
  • Glioma
  • Neuro-oncology
  • Pediatric patients

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Surgery
  • Clinical Neurology


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