TY - JOUR
T1 - Pediatric brainstem gliomas
T2 - A retrospective study of 180 patients from the seer database
AU - Khalid, Syed I.
AU - Kelly, Ryan
AU - Adogwa, Owoicho
AU - Carlton, Adam
AU - Tam, Edric
AU - Naqvi, Salik
AU - Kushkuley, Jacob
AU - Ahmad, Shahjehan
AU - Woodward, Josha
AU - Khanna, Ryan
AU - Davison, Mark
AU - Munoz, Lorenzo
AU - Byrne, Richard
PY - 2019/7/1
Y1 - 2019/7/1
N2 - Background/Aims: Large population-based studies are needed to assess the epidemiology and survival risk factors associated with pediatric brainstem gliomas. This retrospective study explores factors that may influence survival in this population. Methods: Utilizing the SEER database, the authors retrospectively assessed survival in histologically confirmed brainstem gliomas in patients aged 17 and younger. Survival was described with Kaplan-Meyer curves and multivariate regression analysis. Results: This analysis of 180 cases showed that age (hazard ratio [HR] 1.04, 95% CI 0.96-1.14, p = 0.34), non-white race (HR 1.00, 95% CI 0.35-2.85 p > 0.99), distant or invasive extension of the tumor (HR 0.4, 95% CI 0.08-2.53, p = 0.37), and radiation therapy (HR 1.27, 95% CI 0.52-3.11, p = 0.61) were not associated with decreased survival. High-grade tumor status (HR 8.64, 95% CI 3.49-21.41, p < 0.001) was associated with decreased survival. Partial resection (HR 0.11, 95% CI 0.04-0.30, p < 0.001) and gross-Total resection (HR 0.03, 95% CI 0.01-0.14, p < 0.001) were associated with improved survival. Conclusions: High-grade brainstem gliomas have a worse prognosis. Early diagnosis and surgery appear to be associated with improved survival, while the role of radiation is unclear.
AB - Background/Aims: Large population-based studies are needed to assess the epidemiology and survival risk factors associated with pediatric brainstem gliomas. This retrospective study explores factors that may influence survival in this population. Methods: Utilizing the SEER database, the authors retrospectively assessed survival in histologically confirmed brainstem gliomas in patients aged 17 and younger. Survival was described with Kaplan-Meyer curves and multivariate regression analysis. Results: This analysis of 180 cases showed that age (hazard ratio [HR] 1.04, 95% CI 0.96-1.14, p = 0.34), non-white race (HR 1.00, 95% CI 0.35-2.85 p > 0.99), distant or invasive extension of the tumor (HR 0.4, 95% CI 0.08-2.53, p = 0.37), and radiation therapy (HR 1.27, 95% CI 0.52-3.11, p = 0.61) were not associated with decreased survival. High-grade tumor status (HR 8.64, 95% CI 3.49-21.41, p < 0.001) was associated with decreased survival. Partial resection (HR 0.11, 95% CI 0.04-0.30, p < 0.001) and gross-Total resection (HR 0.03, 95% CI 0.01-0.14, p < 0.001) were associated with improved survival. Conclusions: High-grade brainstem gliomas have a worse prognosis. Early diagnosis and surgery appear to be associated with improved survival, while the role of radiation is unclear.
KW - Brainstem
KW - Glioma
KW - Neuro-oncology
KW - Pediatric patients
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U2 - 10.1159/000497440
DO - 10.1159/000497440
M3 - Article
C2 - 30947221
AN - SCOPUS:85064053575
SN - 1016-2291
VL - 54
SP - 151
EP - 164
JO - Pediatric Neurosurgery
JF - Pediatric Neurosurgery
IS - 3
ER -