PD-1 shapes B cells as evildoers in the tumor microenvironment

Zhenhua Ren, Hua Peng, Yang Xin Fu

Research output: Contribution to journalArticlepeer-review

27 Scopus citations


Protumorigenic PD-1hi B cells, induced in hepatocellular carcinoma, suppress tumor-specific T-cell response via IL10-dependent pathways upon PD-1/PD-L1 interaction. Anti–PD-1 or anti–PD-L1 antibodies may function not only through blocking the PD-1 coinhibitory pathway in T cells but also via abolishing the suppressive function of regulatory B cells.

Original languageEnglish (US)
Pages (from-to)477-478
Number of pages2
JournalCancer discovery
Issue number5
StatePublished - May 2016

ASJC Scopus subject areas

  • Oncology


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