PD-1 shapes B cells as evildoers in the tumor microenvironment

Zhenhua Ren; Hua Peng; Yang Xin Fu

doi:10.1158/2159-8290.CD-16-0307

PD-1 shapes B cells as evildoers in the tumor microenvironment

Zhenhua Ren, Hua Peng, Yang Xin Fu

Research output: Contribution to journal › Article › peer-review

31 Scopus citations

Abstract

Protumorigenic PD-1^hi B cells, induced in hepatocellular carcinoma, suppress tumor-specific T-cell response via IL10-dependent pathways upon PD-1/PD-L1 interaction. Anti–PD-1 or anti–PD-L1 antibodies may function not only through blocking the PD-1 coinhibitory pathway in T cells but also via abolishing the suppressive function of regulatory B cells.

Original language	English (US)
Pages (from-to)	477-478
Number of pages	2
Journal	Cancer discovery
Volume	6
Issue number	5
DOIs	https://doi.org/10.1158/2159-8290.CD-16-0307
State	Published - May 2016

ASJC Scopus subject areas

Oncology

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10.1158/2159-8290.CD-16-0307

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title = "PD-1 shapes B cells as evildoers in the tumor microenvironment",

abstract = "Protumorigenic PD-1hi B cells, induced in hepatocellular carcinoma, suppress tumor-specific T-cell response via IL10-dependent pathways upon PD-1/PD-L1 interaction. Anti–PD-1 or anti–PD-L1 antibodies may function not only through blocking the PD-1 coinhibitory pathway in T cells but also via abolishing the suppressive function of regulatory B cells.",

author = "Zhenhua Ren and Hua Peng and Fu, {Yang Xin}",

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AB - Protumorigenic PD-1hi B cells, induced in hepatocellular carcinoma, suppress tumor-specific T-cell response via IL10-dependent pathways upon PD-1/PD-L1 interaction. Anti–PD-1 or anti–PD-L1 antibodies may function not only through blocking the PD-1 coinhibitory pathway in T cells but also via abolishing the suppressive function of regulatory B cells.

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PD-1 shapes B cells as evildoers in the tumor microenvironment

Abstract

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