@article{dc31c5cb2cc4461abf8e397abdee620d,
title = "Patterns of Oxygenation, Mortality, and Growth Status in the Surfactant Positive Pressure and Oxygen Trial Cohort",
abstract = "Objective To characterize actual achieved patterns of oxygenation in infants born appropriate vs small for gestational age (SGA) randomized to a lower (85-89%) vs higher (91%-95%) oxygen saturation target in the Surfactant Positive Pressure and Oxygen Trial. To determine the association between achieved oxygen saturation levels and survival in infants born appropriate vs SGA enrolled in the Surfactant Positive Pressure and Oxygen Trial. Study design Median oxygen saturation and intermittent hypoxemia events (<80%, 20 seconds-5 minutes) were documented in 1054 infants of 240/7-276/7 weeks of gestation while receiving supplemental oxygen during the first 3 days of life. Results Lower target infants who were small for gestational age had the lowest oxygen saturation and highest incidence of intermittent hypoxemia during the first 3 days of life. The lowest quartile of oxygen saturation (≤92%) during the first 3 days of life was associated with lower 90-day survival for both infants born appropriate and SGA. An increased incidence of intermittent hypoxemia events during the first 3 days of life was associated with lower 90-day survival only in infants born SGA. Conclusion Lower achieved oxygen saturation during the first 3 days of life was associated with lower 90-day survival in extremely preterm infants. Infants born SGA had enhanced vulnerability to lower oxygen saturation targets as evidenced by lower achieved oxygen saturation and an association between increased intermittent hypoxemia events and lower survival. Trial registration ClinicalTrials.gov: NCT00233324.",
keywords = "hypoxia, intermittent hypoxemia, oxygen saturation, small for gestational age, supplemental oxygen",
author = "{SUPPORT Study Group of the Eunice Kennedy Shriver National Institute of Child Health, and Human Development Neonatal Research Network} and {Di Fiore}, {Juliann M.} and Martin, {Richard J.} and Hong Li and Nathan Morris and Carlo, {Waldemar A.} and Neil Finer and Michele Walsh and Jobe, {Alan H.} and Caplan, {Michael S.} and Polin, {Richard A.} and Laptook, {Abbot R.} and William Oh and Hensman, {Angelita M.} and Dan Gingras and Susan Barnett and Sarah Lillie and Kim Francis and Dawn Andrews and Kristen Angela and Fanaroff, {Avroy A.} and Newman, {Nancy S.} and Siner, {Bonnie S.} and Arlene Zadell and Kurt Schibler and Donovan, {Edward F.} and Kate Bridges and Barbara Alexander and Cathy Grisby and Mersmann, {Marcia Worley} and Mincey, {Holly L.} and Jody Hessling and Goldberg, {Ronald N.} and Cotten, {C. Michael} and Wallace, {David K.} and Freedman, {Sharon F.} and Auten, {Kathy J.} and Fisher, {Kimberly A.} and Foy, {Katherine A.} and Stoll, {Barbara J.} and Piazza, {Anthony J.} and Susie Buchter and Carlton, {David P.} and Hutchinson, {Amy K.} and Hale, {Ellen C.} and Higgins, {Rosemary D.} and Archer, {Stephanie Wilson} and Poindexter, {Brenda B.} and S{\'a}nchez, {Pablo J.} and Faithe Hamer and Rosenfeld, {Charles R.}",
note = "Funding Information: Supported by The National Institutes of Health (NIH), the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), the National Heart, Lung, and Blood Institute (NHLBI), and the National Center for Research Resources, and the National Center for Advancing Translational Sciences (1RO3HD078528-01A1, U10 HD21364, U10 HD21373, U10 HD21385, U10 HD21397, U10 HD27851, U10 HD27853, U10 HD27856, U10 HD27880, U10 HD27871, U10 HD27904, U10 HD34216, U10 HD36790, U10 HD40461, U10 HD40492, U10 HD40498, U10 HD40521, U10 HD40689, U10 HD53089, U10 HD53109, U10 HD53119, and U10 HD53124, M01 RR30, M01 RR32, M01 RR39, M01 RR44, M01 RR54, M01 RR59, M01 RR64, M01 RR70, M01 RR80, MO1 RR125, M01 RR633, M01 RR750, M01 RR997, M01 RR6022, M01 RR7122, M01 RR8084, M01 RR16587, UL1 RR25008, UL1 RR24139, UL1 RR24979, and UL1 RR25744). Participating Neonatal Research Network (NRN) sites collected and transmitted data to RTI International, the data coordinating center (DCC) for the network, which stored, and managed the data for this study. The authors declare no conflicts of interest. Publisher Copyright: {\textcopyright} 2017 Elsevier Inc.",
year = "2017",
month = jul,
doi = "10.1016/j.jpeds.2017.01.057",
language = "English (US)",
volume = "186",
pages = "49--56.e1",
journal = "Journal of Pediatrics",
issn = "0022-3476",
publisher = "Mosby Inc.",
}