Pathophysiology of cholesterol gallstone disease

Piero Portincasa, Antonio Moschetta, Agostino Di Ciaula, Daniela Pontrelli, Rosa C. Sasso, Helen H. Wang, David Q H Wang

Research output: Chapter in Book/Report/Conference proceedingChapter

9 Scopus citations


Gallstone disease is one of the most costly digestive diseases requiring hospitalization in westernized countries, and its prevalence ranges from 10% to 15% in adults in Europe and the USA [1-4]. The burden of disease is summarized by the prevalence of patients with gallstones, by its incidence (over a million new diagnoses of gallstones a year), and by the number of cholecystectomies performed yearly in the USA (approaching 700,000) [5]. Similar trends in gallstone disease have been confirmed in large epidemiological surveys carried out in Italy [6-10]. In Western societies approximately 80% of gallstones are cholesterol gallstones [11], either pure cholesterol or mixed cholesterol stones (containing more than 50% cholesterol by weight).

Original languageEnglish (US)
Title of host publicationBiliary Lithiasis
Subtitle of host publicationBasic Science, Current Diagnosis and Management
PublisherSpringer Milan
Number of pages31
ISBN (Print)9788847007628
StatePublished - Dec 1 2008

ASJC Scopus subject areas

  • Medicine(all)


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