Pathophysiology, Classifications, and Natural History of Perthes Disease

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58 Scopus citations


Since the original reports of Legg-Calvé-Perthes disease (LCPD), much research effort has been undertaken to improve understanding of this idiopathic hip disorder. This article focuses on the current knowledge of the pathophysiology, classifications, and natural history of LCPD. Although the cause of LCPD remains largely unknown, some insight has been gained on its pathophysiology through experimental studies using animal models of ischemic necrosis. The few available clinical studies on the natural history of LCPD suggest that femoral head deformity is well tolerated in short and intermediate terms, but 50% of patients develop disabling arthritis in the sixth decade of life.

Original languageEnglish (US)
Pages (from-to)285-295
Number of pages11
JournalOrthopedic Clinics of North America
Issue number3
StatePublished - Jul 2011


  • Avascular necrosis
  • Classifications
  • Femoral Head
  • Ischemic necrosis
  • Legg-Calvé-Perthes disease
  • Natural History
  • Pathophysiology
  • Pediatric

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine


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