Pathological Gambling: A Psychobiological Study

A. Roy; B. Adinoff; L. Roehrich; D. Lamparski; R. Custer; V. Lorenz; M. Barbaccia; A. Guidotti; E. Costa; M. Linnoila

doi:10.1001/archpsyc.1988.01800280085011

Pathological Gambling: A Psychobiological Study

A. Roy, B. Adinoff, L. Roehrich, D. Lamparski, R. Custer, V. Lorenz, M. Barbaccia, A. Guidotti, E. Costa, M. Linnoila

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197 Scopus citations

Abstract

We investigated psychobiological substrates of pathological gambling by measuring levels of norepinephrine, monoamine metabolites, and peptides in cerebrospinal fluid, plasma, and urine. Pathological gamblers had a significantly higher centrally produced fraction of cerebrospinal fluid levels of 3-methoxy-4-hydroxyphenylglycol as well as significantly greater urinary outputs of norepinephrine than controls. These results suggest that pathological gamblers may have a functional disturbance of the noradrenergic system. This system has been postulated to underlie sensation-seeking behaviors, aspects of which are thought to be abnormal among pathological gamblers.

Original language	English (US)
Pages (from-to)	369-373
Number of pages	5
Journal	Archives of General Psychiatry
Volume	45
Issue number	4
DOIs	https://doi.org/10.1001/archpsyc.1988.01800280085011
State	Published - Apr 1988

ASJC Scopus subject areas

Arts and Humanities (miscellaneous)
Psychiatry and Mental health

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AU - Adinoff, B.

AU - Roehrich, L.

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AU - Lorenz, V.

AU - Barbaccia, M.

AU - Guidotti, A.

AU - Costa, E.

AU - Linnoila, M.

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Pathological Gambling: A Psychobiological Study

Abstract

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