Pathologic HIF1α signaling drives adipose progenitor dysfunction in obesity

Mengle Shao; Chelsea Hepler; Qianbin Zhang; Bo Shan; Lavanya Vishvanath; Gervaise H. Henry; Shangang Zhao; Yu A. An; Yibo Wu; Douglas W. Strand; Rana K. Gupta

doi:10.1016/j.stem.2020.12.008

Pathologic HIF1α signaling drives adipose progenitor dysfunction in obesity

Mengle Shao, Chelsea Hepler, Qianbin Zhang, Bo Shan, Lavanya Vishvanath, Gervaise H. Henry, Shangang Zhao, Yu A. An, Yibo Wu, Douglas W. Strand, Rana K. Gupta

Research output: Contribution to journal › Article › peer-review

53 Scopus citations

Abstract

How adipocyte precursor cells are regulated to control depot-specific adipose tissue expansion in obesity remains unclear. Here, Shao et al. identify a HIFα-dependent regulatory mechanism controlling adipocyte progenitor activity in mice and demonstrate the ability of the anti-cancer drug Imatinib to promote metabolically beneficial adipogenesis in obesity.

Original language	English (US)
Pages (from-to)	685-701.e7
Journal	Cell Stem Cell
Volume	28
Issue number	4
DOIs	https://doi.org/10.1016/j.stem.2020.12.008
State	Published - Apr 1 2021

Keywords

Adipocyte precursor cell
Adipogenesis
Fibrosis
HIF1α
Imatinib
PDGFR
PPARγ

ASJC Scopus subject areas

Molecular Medicine
Genetics
Cell Biology

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10.1016/j.stem.2020.12.008

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title = "Pathologic HIF1α signaling drives adipose progenitor dysfunction in obesity",

abstract = "How adipocyte precursor cells are regulated to control depot-specific adipose tissue expansion in obesity remains unclear. Here, Shao et al. identify a HIFα-dependent regulatory mechanism controlling adipocyte progenitor activity in mice and demonstrate the ability of the anti-cancer drug Imatinib to promote metabolically beneficial adipogenesis in obesity.",

keywords = "Adipocyte precursor cell, Adipogenesis, Fibrosis, HIF1α, Imatinib, PDGFR, PPARγ",

author = "Mengle Shao and Chelsea Hepler and Qianbin Zhang and Bo Shan and Lavanya Vishvanath and Henry, {Gervaise H.} and Shangang Zhao and An, {Yu A.} and Yibo Wu and Strand, {Douglas W.} and Gupta, {Rana K.}",

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T1 - Pathologic HIF1α signaling drives adipose progenitor dysfunction in obesity

AU - Shao, Mengle

AU - Hepler, Chelsea

AU - Zhang, Qianbin

AU - Shan, Bo

AU - Vishvanath, Lavanya

AU - Henry, Gervaise H.

AU - Zhao, Shangang

AU - An, Yu A.

AU - Wu, Yibo

AU - Strand, Douglas W.

AU - Gupta, Rana K.

PY - 2021/4/1

Y1 - 2021/4/1

N2 - How adipocyte precursor cells are regulated to control depot-specific adipose tissue expansion in obesity remains unclear. Here, Shao et al. identify a HIFα-dependent regulatory mechanism controlling adipocyte progenitor activity in mice and demonstrate the ability of the anti-cancer drug Imatinib to promote metabolically beneficial adipogenesis in obesity.

AB - How adipocyte precursor cells are regulated to control depot-specific adipose tissue expansion in obesity remains unclear. Here, Shao et al. identify a HIFα-dependent regulatory mechanism controlling adipocyte progenitor activity in mice and demonstrate the ability of the anti-cancer drug Imatinib to promote metabolically beneficial adipogenesis in obesity.

KW - Adipocyte precursor cell

KW - Adipogenesis

KW - Fibrosis

KW - HIF1α

KW - Imatinib

KW - PDGFR

KW - PPARγ

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ER -

Pathologic HIF1α signaling drives adipose progenitor dysfunction in obesity

Abstract

Keywords

ASJC Scopus subject areas

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