@article{9b575ad82bcb4e1582ae3774b31e4a2f,
title = "Pathologic HIF1α signaling drives adipose progenitor dysfunction in obesity",
abstract = "How adipocyte precursor cells are regulated to control depot-specific adipose tissue expansion in obesity remains unclear. Here, Shao et al. identify a HIFα-dependent regulatory mechanism controlling adipocyte progenitor activity in mice and demonstrate the ability of the anti-cancer drug Imatinib to promote metabolically beneficial adipogenesis in obesity.",
keywords = "Adipocyte precursor cell, Adipogenesis, Fibrosis, HIF1α, Imatinib, PDGFR, PPARγ",
author = "Mengle Shao and Chelsea Hepler and Qianbin Zhang and Bo Shan and Lavanya Vishvanath and Henry, {Gervaise H.} and Shangang Zhao and An, {Yu A.} and Yibo Wu and Strand, {Douglas W.} and Gupta, {Rana K.}",
note = "Funding Information: The authors thank P. Scherer for providing the TRE-Hif1a DN transgenic mice and C. Kusminski and N. Joffin for critical reading of the manuscript. The authors thank C. Lee, the UTSW Animal Resource Center, Metabolic Phenotyping Core, Pathology Core, Live Cell Imaging Core, Flow Cytometry Core, McDermott Sequencing Center, and Proteomics Core for excellent assistance with experiments performed here, along with A. Banks (Boston, MA) for useful discussions and critical reagents. This study and/or personnel were supported in part by NIDDK F31DK113696 to C.H.; ADA 1-17-IBS-181 and NIDDK awards R01 DK104789 , RC2 DK118620 , and R01 DK119163 to R.K.G.; AHA awards 16POST26420136 and 19CDA34670007 to M.S.; and NIDDK R01 DK115477 to D.W.S. Y.W. is supported by the Grant-in-aid for Scientific Research (B) 18H02425 from the Japan Society for the Promotion of Science . Publisher Copyright: {\textcopyright} 2020 Elsevier Inc.",
year = "2021",
month = apr,
day = "1",
doi = "10.1016/j.stem.2020.12.008",
language = "English (US)",
volume = "28",
pages = "685--701.e7",
journal = "Cell Stem Cell",
issn = "1934-5909",
publisher = "Cell Press",
number = "4",
}