TY - JOUR
T1 - Pathogenicity of anti-DNA/glomerular autoantibodies - Weighing the evidence
AU - Limaye, Nisha
AU - Mohan, Chandra
PY - 2004/12
Y1 - 2004/12
N2 - Systematic lupus erythematosus (SLE) is an autoimmune disease characterized by the appearance of autoantibodies against a variety of nucleosomal and kidney antigens. Targeting of glomeruli, the basic units of filtration in the kidneys, by these autoantibodies is one of the crucial events initiating nephritis, leading to the chronic renal insufficiency seen in lupus. Here we review published reports that directly tested the in vivo pathogenicity of antinuclear/glomerular autoantibodies, which indicate that intermediating nucleosomal bridges might be what empower antibodies to target glomeruli. Further studies that systematically evaluate the contribution of clearly non-DNA binding nephritogenic antibodies, and elucidate the additional factors essential for renal pathology to ensue once the golmeruli are targeted, remain to be done.
AB - Systematic lupus erythematosus (SLE) is an autoimmune disease characterized by the appearance of autoantibodies against a variety of nucleosomal and kidney antigens. Targeting of glomeruli, the basic units of filtration in the kidneys, by these autoantibodies is one of the crucial events initiating nephritis, leading to the chronic renal insufficiency seen in lupus. Here we review published reports that directly tested the in vivo pathogenicity of antinuclear/glomerular autoantibodies, which indicate that intermediating nucleosomal bridges might be what empower antibodies to target glomeruli. Further studies that systematically evaluate the contribution of clearly non-DNA binding nephritogenic antibodies, and elucidate the additional factors essential for renal pathology to ensue once the golmeruli are targeted, remain to be done.
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U2 - 10.1016/j.ddmod.2004.11.008
DO - 10.1016/j.ddmod.2004.11.008
M3 - Review article
AN - SCOPUS:23744457014
SN - 1740-6757
VL - 1
SP - 395
EP - 403
JO - Drug Discovery Today: Disease Models
JF - Drug Discovery Today: Disease Models
IS - 4
ER -